A case report of undifferentiated carcinoma with osteoclast-like giant cells of the pancreas and literature review

Togawa, Yasuhiro; Tonouchi, Akihiko; Chiku, Tsuyoshi; Sano, Wataru; Doki, Tomoko; Yano, Kentaro; Uno, Hiroyuki; Muronoi, Tomohiro; Kaneoya, Katsuhiko; Shinagawa, Takashi; Harigaya, Kenichi; Toyoda, Akihiro

doi:10.1007/s12328-010-0160-2

Cited by 18 publications

(17 citation statements)

References 27 publications

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“…They are not present in normal tissues other than bones. Nevertheless, similar cells have been found in tumors of pancreas (Abid and Gnanajothy, 2019;Njoumi et al, 2014;Sah et al, 2015;Togawa et al, 2010;Bauditz et al, 2006), liver (Bauditz et al, 2006;Dioscoridi et al, 2015;Ikeda et al, 2003;Kuwano et al, 1984;Rosai, 1990), skin (Goel et al, 2011;Al-Brahim and Salama, 2005;Jiménez-Heffernan et al, 2018;Houang et al, 2015), lung (Nakahashi et al, 1987;Matsukuma et al, 2014;Lindholm et al, 2019;Kong et al, 2015;Dahm, 2017), breast (Stewart and Mutch, 1991;Agnantis and Rosen, 1979;Fadare and Gill, 2009;Ginter et al, 2015;Ohashi et al, 2018), and in many other tumors. Osteoid and bone formation was found in different cancers, such as breast cancer and melanoma (Hoorweg et al, 1997;Dekkers et al, 2019) These tumors can be considered as degenerated or more severely defected forms of teratomas/teratocarcinomas.…”

Section: Tumor Phenotypic Heterogeneitymentioning

confidence: 58%

Neural is Fundamental: Neural Stemness as the Ground State of Cell Tumorigenicity and Differentiation Potential

Cao

2020

Preprint

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Tumorigenesis is a complex biological phenomenon that includes extensive genetic and phenotypic heterogeneities and complicated regulatory mechanisms. In the recent few years, our studies demonstrate that tumor-initiating cells are similar to neural stem/progenitor cells in regulatory networks, tumorigenicity and pluripotent differentiation potential. In the review, I will make further discussion on these observations and propose a rule of cell biology by integrating these findings with evidence from developmental biology, tumor biology and evolution, which suggests that neural stemness underlies two coupled cell properties, tumorigenicity and pluripotent differentiation potential. Tumorigenicity and phenotypic heterogeneity in tumor is a result of acquirement of neural stemness in cells. The neural stemness property of tumor-initiating cells can hopefully integrate different concepts/hypotheses underlying tumorigenesis. Neural stem cells/neural progenitors and tumor-initiating cells share regulatory networks; both exhibit neural stemness, tumorigenicity and differentiation potential; both are dependent on expression or activation of ancestral genes (the atavistic effect); both rely primarily on aerobic glycolytic metabolism; both can differentiate into various cells or tissues that are derived from three germ layers, resembling severely disorganized or more severely degenerated process of embryonic development; both are enriched in long genes with more splice variants that provide more plastic scaffolds for cell differentiation, etc. The property of neural stemness might be a key point to understand tumorigenesis and pluripotent differentiation potential, and possibly explain certain pathological observations in tumors that have been inexplicable. Therefore, behind the complexity of tumorigenesis might be a general rule of cell biology, i.e., neural stemness represents the ground state of cell tumorigenicity and pluripotent differentiation potential.

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Section: Tumor Phenotypic Heterogeneitymentioning

confidence: 58%

Neural is Fundamental: Neural Stemness as the Ground State of Cell Tumorigenicity and Differentiation Potential

Cao

2020

Preprint

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“…Bile duct dilatation, pancreatic duct dilatation and necrotic areas are common findings (54,55). Calcification (56), hemorrhage (56,57), and venous tumor thrombus (57) have also been described. At abdominal MRI UC-OGC usually presents a low to dark signal intensity on T1-and T2-weighted images.…”

Section: Diagnosismentioning

confidence: 99%

Undifferentiated Pancreatic Carcinoma With Osteoclast-Like Giant Cells: What Do We Know So Far?

et al. 2021

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Undifferentiated carcinoma of the pancreas is an aggressive but rare tumor for which several other terms have been used to describe its histological appearance. In addition, as osteoclast-like giant cells may accompany undifferentiated carcinoma of the pancreas, the WHO Classification distinguishes undifferentiated carcinoma with osteoclast-like giant cells (UC-OGC) from plain undifferentiated carcinoma since there are a few histopathological and clinical differences. UC-OGC was initially thought to be associated with worse prognosis compared to invasive ductal pancreatic adenocarcinoma, since it is often unresectable at diagnosis and tends to recur rapidly even if completely resected. When true UC-OGGs are carefully dissected out from other anaplastic carcinomas, it becomes, however, clear that UC-OGCs do have more indolent behavior, especially the pure UC-OGCs. This mini-review summarizes the current knowledge on UC-OGC.

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“…In addition, it has been reported that UCP may arise from cystic neoplasms, such as mucinous cystic neoplasms (MCNs) and intraductal papillary mucinous neoplasms (IPMNs) . However, differential diagnosis of UCP versus UCP arising from cystic neoplasm may be difficult . Furthermore, intraductal tumour growth in the MPD may be mischaracterized as solid intraductal tumours such as IPMN without mucin‐hypersecretion, intraductal tubulopapillary neoplasm (ITPN), and intraductal and papillary variant of acinar cell carcinoma .…”

Section: Discussionmentioning

confidence: 99%

Imaging features of undifferentiated carcinoma of the pancreas

et al. 2019

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Introduction:The purpose of this retrospective study was to evaluate imaging features of undifferentiated carcinoma of the pancreas. Methods: The study group included eight patients with surgically resected undifferentiated carcinoma of the pancreas. Multidetector-row computed tomography (MDCT, n = 8) and magnetic resonance imaging (MRI, n = 6) findings were retrospectively reviewed. Results: On MDCT, all eight cases were hypovascular with upstream main pancreatic duct (MPD) dilatation, and only 1 showed exophytic growth. Five cases (62.5%) showed necrosis/cystic change, and calcification was observed in two cases (25%). Calcification reflected tumour osteoid components. On MRI, haemorrhage and hemosiderin were observed in 4 of 6 (66.7%) cases. In addition, tumour thrombus in the splenic vein (n = 1) and intraductal tumour growth in the MPD (n = 2) were pathologically identified, although imaging studies only revealed 1 of these latter cases. Conclusion: Undifferentiated carcinoma of the pancreas may present as a tumour with haemorrhagic necrosis. Coexistence of calcification, intraductal tumour growth in the MPD and tumour thrombus may support the imaging diagnosis of this entity. MethodsInstitutional review board (IRB) approval was obtained, and the requirements for informed consent were waived due to the retrospective nature of the study. Between

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A case report of undifferentiated carcinoma with osteoclast-like giant cells of the pancreas and literature review

Cited by 18 publications

References 27 publications

Neural is Fundamental: Neural Stemness as the Ground State of Cell Tumorigenicity and Differentiation Potential

Neural is Fundamental: Neural Stemness as the Ground State of Cell Tumorigenicity and Differentiation Potential

Undifferentiated Pancreatic Carcinoma With Osteoclast-Like Giant Cells: What Do We Know So Far?

Imaging features of undifferentiated carcinoma of the pancreas

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