A case report of unusual cavity presentation of pulmonary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue

Abstract

Rationale:The common CT scan findings of pulmonary MZBL of MALT type include airspace consolidation, nodules and ground-glass opacity. But, to our knowledge, the present case is the first report of a cavity presentation of pulmonary MZBL of MALT type.Patient concerns:The patient gives his consent and authorizes the photographs featuring his likeness to be published.Diagnoses:This patient was diagnosed as pulmonary MZBL of MALT type by pathology, immunohistochemistry, and gene rearrangement.Interventions:The patient was treated with CHOP (cyclophosphamide, adriamycin, vincristine and prednisone) chemotherapy for twice and antibiotics.Outcomes:He is being followed up for one year, with slight progress in pulmonary MZBL of MALT.Lessons:This case highlights the need to be suspicious of MZBL of MALT type, when a radiographic image shows cavity lesion. We should consider whether the diagnosis is correct, when the patient's treatment is not effective.

Maltoma veiled in the lung-a rare case of pulmonary and gastric maltoma

“…Mucosa-associated lymphoid tissue (MALT) lymphoma is an extra-nodal low-grade marginal zone B-cell lymphoma. The condition is commonly associated with autoimmune diseases, in particular, autoimmune thyroiditis and Sjogren's syndrome [ 2 ], as well as other chronic inflammatory conditions and site-specific protracted infections [ 1 ]. Implicated microorganisms include Helicobacter pylori, Borrelia burgdorferi, Chlamydia psittaci, and Mycobacterium tuberculosis; associated with gastric MALT lymphoma, B-cell cutaneous lymphoma, ocular adnexal lymphoma, and pulmonary MALT lymphoma, respectively [ 1 ].…”

“…The condition is commonly associated with autoimmune diseases, in particular, autoimmune thyroiditis and Sjogren's syndrome [ 2 ], as well as other chronic inflammatory conditions and site-specific protracted infections [ 1 ]. Implicated microorganisms include Helicobacter pylori, Borrelia burgdorferi, Chlamydia psittaci, and Mycobacterium tuberculosis; associated with gastric MALT lymphoma, B-cell cutaneous lymphoma, ocular adnexal lymphoma, and pulmonary MALT lymphoma, respectively [ 1 ]. While the exact pathology of MALT lymphoma remains unknown, the persistent antigenic exposure and additional oncologic events in extra-nodal tissues are attributed to monoclonal lymphoid hyperplasia and subsequent extranodal lymphoma [ 3 ].…”