2021
DOI: 10.1111/nan.12680
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A case series of Diffuse Glioneuronal Tumours with Oligodendroglioma‐like features and Nuclear Clusters (DGONC)

Abstract: glioneuronal tumour, monosomy 14We read with interest Deng et al.'s recent manuscript concerning a newly molecularly defined glioneuronal CNS tumour entity, termed diffuse glioneuronal tumour with oligodendroglioma-like features and nuclear clusters (DGONC). 1 DGONCs were identified by a distinctive methylation profile that segregated away from previously recognised molecular groups of CNS tumours. On further review, the authors describe DGONCs as a novel glioneuronal tumour with key neuropathological features… Show more

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Cited by 33 publications
(41 citation statements)
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“…Identifying novel tumor types based on their molecular profile is followed by focused histologic and IHC evaluation that frequently detects diagnostic features, which can be assessed with classic technologies. Examples are the primary intracranial sarcoma, DICER1-mutant (22,23), the diffuse glioneuronal tumor with oligodendroglioma-like features and nuclear clusters (24,25), or the recently described neuroepithelial tumor with PATZ1 fusion (26). Rapid progress is being made with artificial intelligence-based analysis of morphologic images, and this may contribute greatly to tumor evaluation (27,28).…”
Section: Reviewmentioning
confidence: 99%
See 1 more Smart Citation
“…Identifying novel tumor types based on their molecular profile is followed by focused histologic and IHC evaluation that frequently detects diagnostic features, which can be assessed with classic technologies. Examples are the primary intracranial sarcoma, DICER1-mutant (22,23), the diffuse glioneuronal tumor with oligodendroglioma-like features and nuclear clusters (24,25), or the recently described neuroepithelial tumor with PATZ1 fusion (26). Rapid progress is being made with artificial intelligence-based analysis of morphologic images, and this may contribute greatly to tumor evaluation (27,28).…”
Section: Reviewmentioning
confidence: 99%
“…Within the category of circumscribed astrocytic gliomas, high-grade astrocytoma with piloid features was newly introduced (125) and astroblastoma, MN1-altered more precisely defined (126,127). Among glioneuronal and neuronal tumors, diffuse leptomeningeal glioneuronal tumor (128) and diffuse glioneuronal tumor with oligodendroglioma-like features and nuclear clusters (24,25), as a provisional tumor type, were newly added.…”
Section: Low-grade Gliomasmentioning
confidence: 99%
“…This was independently confirmed in a separate series that also noted chromosome 1p and 3p loss. 55 The histologic appearance of DGONC may have significant overlap with other tumor types, including oligodendroglioma and CNS-PNET. 54 Genetic alterations typically seen in low-grade glial or glioneuronal tumors, such as FGFR1 and BRAF , have not been identified in sequenced cases.…”
Section: Glioneuronal Tumorsmentioning
confidence: 99%
“… 54 Genetic alterations typically seen in low-grade glial or glioneuronal tumors, such as FGFR1 and BRAF , have not been identified in sequenced cases. 54 , 55 As genetic drivers have yet to be elucidated in this tumor type, DNA methylation profiling remains the only method for its detection.…”
Section: Glioneuronal Tumorsmentioning
confidence: 99%
“…At the other end of the spectrum are studies benefiting from the national networking effect of BRAIN UK and drawing together large number of cases of sometimes uncommon conditions. Examples of such larger studies include of chordoma (221 cases from six centres [30][31][32] ), paediatric brain tumours (488 cases from 14 centres 29,[33][34][35][36][37][38] ) and chronic traumatic encephalopathy (>100 cases from two centres [39][40][41] ). Feedback from researchers indicates that more than half of the studies could not have been performed without BRAIN UK and there was a significant impact on most of the remainder (Figure 2D).…”
Section: Archived Tissue That Would Otherwise Be Unused Has Supported Valuable Researchmentioning
confidence: 99%