A case series of inactivated Japanese encephalitis virus vaccination associated with positive <scp>West Nile</scp> virus blood donor screening nucleic acid tests

Drews, Steven J.; Makowski, Kai; Wood, Heidi; Dimitrova, Kristina; Yan, Matthew; Young, Dale; Skeate, Robert; Ng, Michiko; Hawes, Gordon; Fearon, Margaret; Bigham, Mark

doi:10.1111/trf.15744

Cited by 5 publications

(1 citation statement)

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“…Identification of the molecular features responsible for detection failure has proven essential to improve not only molecular and serological blood screening tests but also both qualitative and quantitative viral diagnosis. Monitoring viral genomic sequences can also allow investigation of cross‐reactive samples leading to false‐positive results, as shown in donors vaccinated against the Japanese encephalitis virus and tested falsely reactive for West Nile virus (WNV) RNA [24]. Characterization of TTIDs is essential for assessing the transmissibility of (re)emerging viruses, and the effectiveness of new screening strategies on the residual risk to blood safety.…”

Section: Introductionmentioning

confidence: 99%

Monitoring viral genomic sequences in transfusion‐transmitted viruses

2023

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Background and Objectives Monitoring genomic sequences of blood‐borne viruses infecting blood donors enables blood operators to undertake molecular epidemiology, confirm transfusion transmission and assess and characterize molecular and serological screening assays. The purpose of the study was to determine how blood operators globally value viral diversity surveillance and to assess its impact. Materials and Methods An electronic questionnaire was developed and circulated to members of the International Society of Blood Transfusion‐transmitted infectious diseases working party. Responses were compiled and complete data sets were analysed. Results Ninety‐seven percent of respondents agreed that monitoring viral genomic sequences was important to blood operators and the transfusion community. However, only 47% of respondents are currently doing this monitoring. The main limitations reported were a lack of financial resources and expertise. Sequencing techniques, primarily next‐generation sequencing and also Sanger sequencing, were considered most appropriate, with the preferred option for testing being regional or national reference centres. Respondents agreed that engagement with public health authorities needs to be enhanced. Conclusion Monitoring genomic sequences of blood‐borne viruses is widely considered important by the transfusion community because of its direct applications for transfusion safety, and beyond for public health in general. Therefore, there is a need to strengthen collaboration between blood operators and public health authorities. While national and regional reference centres may be the most appropriate structure for such testing, international collaborations should not be overlooked. Overcoming financial barriers will be an important hurdle for many.

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Section: Introductionmentioning

confidence: 99%