A case series of invasive mucormycosis in patients with COVID-19 infection

Abstract

<p class="abstract">Rhino-orbital-cerebral mucormycosis is an invasive disease associated with high mortality ranging from 25-62%. There is an increase in the incidence of mucormycosis in post COVID-19 infection patients. We have come across 10 such patients. On retrospective analysis of the patient’s records, we found that 60% patients had received steroids and majority had co-morbidities. All the patients received similar treatment with IV amphotericin B and local debridement and the mortality rate was as high as 44%. We conclude that patients with COVID 19 infection are susceptible to mucormycosis because of impairment of barrier defense, dysfunction phagocytes and lymphocytes and the use of immunosuppressive medications such as steroids and tocilizumab.</p>

Review of Published Case Reports of COVID-19 Associated Mucormycosis with Search of Therapeutic Potential in Ayurveda and Homeopathy

“…In the third step, all the Vol.11; Issue: 8; August 2021 findings were analyzed and concluded in a manner to put some factual solution. [7][8][9][10][11][12][13][14][15][16][17][18][19][20] In these patients, gender-wise 65.2% (30) male and 34.8% female (16) are seen. Mean age was found 49.9 years age (38-78 years).…”

Mucormycosis: A manifestation in COVID-19 infection

“…[4][5][6][7] Mucormycosis refers to a group of saprophytic fungi that are found in decaying vegetation and food containing high sugar content and these organisms are omnipresent in nature. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] Mucormycosis, also known as zygomycosis and phycomycosis is a rare and lethal disease caused by a common fungus that is part of the class Zygomycetes and classified as mucorales and entomophthorales. The clinical presentation of mucormycosis differs depending on the location of the disease.…”

“…The clinical presentation of mucormycosis differs depending on the location of the disease. [2][3][4][5][6][7][8][9][17][18][19][20][21][22][23][24][25][26] The Entomophthorales are rare causes of subcutaneous and mucocutaneous infections which is known as entomophthoromycosis, which mainly afflict immunosuppressed individuals in developing countries. 27 Mucormycosis is characterized as rhinocerebral, pulmonary, cutaneous, gastrointestinal, disseminated or further, which consist of infection of bones, heart, ear, parotid gland, uterus, urinary bladder and lymph nodes.…”

“…27 Mucormycosis is characterized as rhinocerebral, pulmonary, cutaneous, gastrointestinal, disseminated or further, which consist of infection of bones, heart, ear, parotid gland, uterus, urinary bladder and lymph nodes. 6,7,[9][10][11][12][13][14][15][16]28,29 Rhinocerebral mucormycosis occurs most frequently in diabetic patients, while pulmonary mucormycosis is most common in patients with hematological malignancies. 14 It is a rare but serious persistent fungal infection going on usually in immunosuppressed patients, particularly in patient who have uncontrolled diabetes or hematological deficiency, high iron deficiency, severe trauma, long-term use of corticosteroids, drug abuse, childhood malnutrition, malnutrition and other chronic disease.…”

“…However, the occurrence of intestinal mucormycosis raises an increased possibility of the emergence of severe fungal strains. [2][3][4][5][6][7][8][9][10][11][21][22][23][24][25][26]…”