A case series of nephrogenic adenoma of the urethra and bladder in children: Review of this rare diagnosis, its natural history and management, with reference to the literature

Crook, Tim; Mead, Zoe; Vadgama, Bhumita; Malone, P.S.

doi:10.1016/j.jpurol.2006.02.004

Cited by 16 publications

(12 citation statements)

References 27 publications

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“…There is a 3:1 female predominance and recurrence rate ranges between 37.5-75% during long-term follow-up of pediatric patients. [4,9] NA is believed to have no malignant potential. Although development of malignancy from NA in adults has been reported, no case of malignant transformation has been reported in pediatric patients.…”

Section: Discussionmentioning

confidence: 99%

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Recurrence of childhood nephrogenic adenoma in urinary bladder developed four years after previous surgery despite intravesical sodium hyaluronate therapy

Özçift

Kaçar

Tiryaki

2016

Turkish Journal of Urology

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Nephrogenic adenoma (NA) is a rarely seen benign metaplastic lesion of the urinary tract. Its etiology is uncertain, but induced by chronic inflammation, irritation, and trauma. NA is located in the urinary tract, most commonly in the bladder. NA usually presents with hematuria and lower urinary tract symptoms. In the literature it is mostly seen in adults but about 30 cases of NA's have been reported in children. Treatment of intravesical lesions consists of transurethral resection (TUR) and fulguration and rarely partial or total cystectomy may be required in ineffective TUR. Recurrence rate is high during long-term follow-up. The intravesical application of sodium hyaluronate produces a protective effect on the glycosaminoglycan layer and delays or prevents its recurrence. We report a case of recurrent NA of the bladder in a pediatric male patient who was presented four years after previous surgery despite intravesical sodium hyaluronate therapy.

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Section: Discussionmentioning

confidence: 99%

“…[1][2][3] Presentation in children represents only a small proportion of NA cases which has a high recurrence rate. [4] The symptoms are not specific. Clinical presentation consists of hematuria (40%), suprapubic pain (15%), flank pain (5%) or irritative voiding symptoms.…”

Section: Introductionmentioning

confidence: 99%

Recurrence of childhood nephrogenic adenoma in urinary bladder developed four years after previous surgery despite intravesical sodium hyaluronate therapy

Özçift

Kaçar

Tiryaki

2016

Turkish Journal of Urology

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“…Several hundred cases have been reported worldwide. [1][2][3][4][5] Its etiology is unknown, but it has been linked to chronic irritating factors, such as infection, trauma, urological surgery, kidney stones, foreign bodies and chemical agents, such as Bacille Calmette-Guerin (BCG). Davis published the first case in the literature in 1949.…”

Section: Introductionmentioning

confidence: 99%

Vesical nephrogenic adenoma: an unusual presentation of a bladder tumour

Martínez-Sanchiz

Martínez-Ruiz

Anguita-Fernandez

et al. 2013

CUAJ

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Vesical nephrogenic adenoma is a rare, benign entity that appears most commonly in middle-aged males. Its etiology is unknown, but it has been linked to chronic irritating factors, such as infection, trauma, urological surgery, kidney stones, foreign bodies and chemical agents, such as Bacille Calmette-Guerin. We report 2 new cases with a history of transurethral resection of the bladder and the prostate and a history of prolonged voiding symptoms. In both cases, the findings of encysted tubular structures lined with flattened cuboidal cells without atypia were consistent with the diagnosis of vesical nephrogenic adenoma. IntroductionVesical nephrogenic adenoma is a rare, benign entity that appears most commonly in middle-aged males. Several hundred cases have been reported worldwide.1-5 Its etiology is unknown, but it has been linked to chronic irritating factors, such as infection, trauma, urological surgery, kidney stones, foreign bodies and chemical agents, such as Bacille Calmette-Guerin (BCG). Davis published the first case in the literature in 1949. 6 The term "nephrogenic adenoma" was coined in 1950 by Friedman and Kuhlenbeck, who noted the resemblance of this lesion to the renal tubule.1 Two cases of vesical nephrogenic adenoma will be presented. Case 1A 60-year-old male with a diagnosis of chronic renal failure was seen for severe voiding symptoms and hematuria. The patient was on hemodialysis and had a history of a transurethral resection of the prostate and a bladder diverticulectomy after a transurethral resection of bladder neck. An ultrasound scan revealed a raised intra-vesical lesion. Cystoscopy showed multiple trabeculae and diverticulae of the bladder and, in the left side, a superficial papillary lesion 3 cm in diameter, which was resected. The histological study showed the presence of focal ducts lined with cuboidal epithelium without atypia, located in areas of urothelial denudation ( Fig. 1), findings compatible with vesical nephrogenic adenoma. Currently, the patient is asymptomatic, undergoes regular check-ups and is waiting for a kidney transplant due to end-stage renal disease. Case 2An 80-year-old male was seen for a consultation for hematuria. The patient had a history of two previous transurethral resections for a bladder tumour and benign prostatic hyperplasia. An ultrasound revealed a small lesion on the right side. Cystoscopy showed a 1-cm lesion in the perimeatic area, which was resected. The histological study showed encysted tubular structures lined with flattened cuboidal cells, consistent with vesical nephrogenic adenoma (Fig. 2). The patient is currently being monitored, and his condition is well-controlled. DiscussionNephrogenic adenoma (or papillary tubular adenoma) is a rare, benign metaplastic lesion.3 Its most characteristic location is in the bladder, especially in the trigone, but it is also found, to a lesser extent, in the urethra and ureters. Chronic bladder irritation by foreign bodies, trauma, urological surgery, prolonged instrumentation of the urinary...

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“…It has been observed in the renal pelvis, ureter, bladder, prostate, and urethra [5]. One case of urethral NA in an adult patient with a previous history of hypospadias repaired with a bladder mucosa free graft has also been reported [6].…”

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confidence: 99%

“…A mass mimicking a tumor is usually found on ultrasonography or cystoscopy, and careful examination to exclude exophytic malignant tumors of the urinary tract is mandatory in children [4]. Histologically, tubular structures such as those found in the kidney are observed on microscopic examination, and the epithelial origin of the tumor can be confirmed by use of immunohistologic antibodies [5].…”

mentioning

confidence: 99%

Eosinophilic cystitis and nephrogenic adenoma of the bladder: a rare association of 2 unusual findings in childhood

Rossi¹,

Pavanello²,

Marzola

et al. 2011

Journal of Pediatric Surgery

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A case series of nephrogenic adenoma of the urethra and bladder in children: Review of this rare diagnosis, its natural history and management, with reference to the literature

Cited by 16 publications

References 27 publications

Recurrence of childhood nephrogenic adenoma in urinary bladder developed four years after previous surgery despite intravesical sodium hyaluronate therapy

Recurrence of childhood nephrogenic adenoma in urinary bladder developed four years after previous surgery despite intravesical sodium hyaluronate therapy

Vesical nephrogenic adenoma: an unusual presentation of a bladder tumour

Eosinophilic cystitis and nephrogenic adenoma of the bladder: a rare association of 2 unusual findings in childhood

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