A Case Series of Patients with Large Uterine Fibroids and Venous Thromboembolisms

A rare case of venous sinus thrombosis and pulmonary embolisms secondary to myomatous erythrocytosis syndrome

“… 1 In addition, it has been well-documented that patients with uterine leiomyomas are susceptible to venous thromboembolism, most commonly deep venous thromboembolism (DVT). 5 , 8 , 9 In addition, PEs secondary to uterine leiomyomas have been documented as a rare complication. 5 , 9 Large-size uteri have been shown to cause compressive effects of the pelvic vasculature, leading to venous stasis leading to both DVTs and PE.…”

“… 5 , 8 , 9 In addition, PEs secondary to uterine leiomyomas have been documented as a rare complication. 5 , 9 Large-size uteri have been shown to cause compressive effects of the pelvic vasculature, leading to venous stasis leading to both DVTs and PE. 4 Literature of neurologic complications secondary to uterine leiomyomas is exceptionally rare.…”

Case report: A case of perineal prolapse of giant uterine fibroids complicated by multiple pulmonary embolisms and deep venous thrombosis

“…Studies have reported that the probability of VTE is fourfold higher in cases of uterine fibroids weighing more than 1000 g compared to small fibroids (4). Another research reported that the median uterine volume of women who developed VTE was 2715 mL (5).…”

Venous thromboembolism in a patient with an uncommon etiology of May-Thurner syndrome

“…Although an association between uterine fibroids and VTE is well-documented in the literature, few studies have considered this relationship in the context of secondary MTS from benign gynecologic etiologies. 10 , 11 , 12 , 13 , 14 , 15 , 16 Also, standardized guidelines for the long-term treatment of these patients are lacking. Suggestions have included long-term anticoagulation and gynecology referral for potential hysterectomy or myomectomy.…”

“…Though an association between uterine fibroids and VTE is well-documented in the literature, few publications consider this relationship in the context of secondary MTS from benign gynecological etiologies, and there is a lack of standardized guidelines for the long term management of these patients. [10][11][12][13][14][15][16] Suggestions include long term anticoagulation and gynecology referral for potential hysterectomy or myomectomy. 17,18 Uterine artery embolization is also an option, though this may be associated with a higher risk of fibroid recurrence than hysterectomy or myomectomy and also carries a risk of the post-embolization syndrome.…”