A Case series of Wickerhamomyces anomalus: An emerging fungal pathogen and an entity of concern for neonatal intensive care unit

Paul, Pradeep; Pandey, Nidhi; Gupta, Mukul; Kumar, Dhilip; Tilak, Ragini

doi:10.5455/ijmrcr.wickerhamomyces-anomalus-290

Cited by 4 publications

(5 citation statements)

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“…Wickerhamomyces anomalus (formerly Candida pelliculosa ) is widespread within nature often found in soil and on plant material and is considered a level 1 biosafety organism, safe for healthy humans (Satora et al, 2014). It is an opportunistic pathogen of humans and animals (Kurtzman, 2011) and has been isolated from infected human lungs (Kurtzman, 2011), involved in neonatal fungemia (Paul et al, 2020) and ocular keratitis (Kamoshita et al, 2015) cases. Candida species are well known to colonise the skin and mucosal surfaces of humans and often form biofilms making their eradication challenging (Paul et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…It is an opportunistic pathogen of humans and animals (Kurtzman, 2011) and has been isolated from infected human lungs (Kurtzman, 2011), involved in neonatal fungemia (Paul et al, 2020) and ocular keratitis (Kamoshita et al, 2015) cases. Candida species are well known to colonise the skin and mucosal surfaces of humans and often form biofilms making their eradication challenging (Paul et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…Candida species are well known to colonise the skin and mucosal surfaces of humans and often form biofilms making their eradication challenging (Paul et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

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Diagnosis and unsuccessful management of iatrogenic fungal septic arthritis caused byWickerhamomyces anomalous(formerlyCandida pelliculosa) and concurrent osteochondral lesion in Ireland

Duggan

Gibbons

Offereins³

et al. 2023

Equine Veterinary Education

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Summary Equine septic fungal arthritis is poorly documented in the literature. There is an absence of efficacy and safety data for antifungal medications, highlighting the importance of documenting this case. A 15‐year‐old Irish sport horse gelding presented 4/5 (AAEP) left hindlimb lame 13 days after intra‐articular medication of the left tarsocrural joint with triamcinolone and hyaluronic acid. Radiography revealed an osteochondral fragment at the distal intermediate ridge of the tibia and shallow subchondral bone defect on the medial trochlear ridge. Synoviocentesis yielded a turbid sample with an elevated total nucleated cell count (49 × 109cells/L; total neutrophil count of 62.8%). Arthroscopic lavage of the tarsocrural joint (TCJ) was performed. Ceftriaxone was administered and systemic antimicrobials initiated. The fungus Wickerhamomyces anomalus was identified on culture. The horse was subsequently intensively treated with antimicrobial and antifungal medications, both systemically and intra‐articularly over the following 60 plus days. Multiple subsequent synovial cultures revealed the persistence of the fungal organism, until a negative culture on day 55. However, on day 113, a grade 5/5 lameness was present, and a further positive synovial fungal culture. Radiographs revealed a lytic lesion at the distal tibia with marked progression. The horse was euthanised on day 126.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Diagnosis and unsuccessful management of iatrogenic fungal septic arthritis caused byWickerhamomyces anomalous(formerlyCandida pelliculosa) and concurrent osteochondral lesion in Ireland

Duggan

Gibbons

Offereins³

et al. 2023

Equine Veterinary Education

View full text Add to dashboard Cite

show abstract

“…Wickerhamomyces anomalus (formerly Candida pelliculosa ) is widespread within nature often found in soil and on plant material and is considered a level 1 biosafety organism, safe for healthy humans (Satora et al 2014). It is an opportunistic pathogen of humans and animals (Kurtzman 2011) and has been isolated from infected human lungs (Kurtzman 2011), involved in neonatal fungemia (PAUL et al2020) and ocular keratitis (Kamoshita et al 2015) cases.Candida species are well known to colonise the skin and mucosal surfaces of humans and often form biofilms making their eradication challenging (PAUL et al 2020). Cohen et al, (2008) report a 3-year-old standard-bred filly that developed bacterial metacarpophalangeal joint septic arthritis following IA medication with hyaluronic acid.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and unsuccessful management of iatrogenic fungal septic arthritis caused by Wickerhamomyces anomalous (formerly Candida pelliculosa) and concurrent osteochondral lesion

Duggan

Gibbons

Fogarty

et al. 2022

Preprint

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Equine septic fungal arthritis is poorly documented in the literature. There is absence of efficacy and safety data for anti-fungal medications, highlighting the importance of documenting this case. A 15-year-old Irish sport horse gelding presented moderately lame at the walk on the left hindlimb 13 days after intra-articular medication of the left tarso-crural joint with triamcinolone and hyaluronic acid. Radiography revealed an osteochondral fragment at the distal intermediate ridge of the tibia and shallow subchondral bone defect on the medial trochlear ridge. Synoviocentesis yielded a turbid sample with an elevated total nucleated cell count (49x109cells/L; total neutrophil count of 62.8%). Arthroscopic lavage of the tarsocrural joint (TCJ) was performed. Ceftriaxone was administered and systemic antimicrobials initiated. The fungus Wickerhamomyces anomalus was identified on culture. The horse was subsequently intensively treated with antimicrobial and anti-fungal medications, both systemically and intra-articularly over the following 60 plus days. Multiple subsequent synovial cultures revealed the persistence of the fungal organism, until a negative culture on day 55. However, on day 113, a non-weight bearing lameness at trot was present, and a further positive synovial fungal culture. Radiographs revealed a lytic lesion at the distal tibia with marked progression. The horse was euthanised on day 126.

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“…The strict hand hygiene measures along with fluconazole and nystatin therapy helped in controlling the outbreak [ 8 ]. W. anomalus has become an agent of concern, as several large outbreaks in the neonatal wards have been reported across the world within the last 5 years [ 58 ]. Adhering to strict hand hygiene practices and contact precautions is the key to evade such outbreaks.…”

Section: Introductionmentioning

confidence: 99%

Candidiasis and Other Emerging Yeasts

Sharma

Chakrabarti²

2023

Curr Fungal Infect Rep

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Purpose of Review The review presents a comprehensive and updated information on the contemporary status of invasive candidiasis (IC), other emerging yeast infections, and the challenges they present in terms of at-risk population, specific virulence attributes, and antifungal susceptibility profile. Recent Findings With the advancement in medical field, there has been parallel expansion of vulnerable populations over the past two decades. This had led to the emergence of a variety of rare yeasts in healthcare settings, both Candida and non-Candida yeast causing sporadic cases and outbreaks. The advancements in diagnostic modalities have enabled accurate identification of rare Candida species and non-Candida yeast (NCY) of clinical importance. Their distribution and susceptibility profile vary across different geographical regions, thus necessitating surveillance of local epidemiology of these infections to improve patient outcomes. Summary The challenges in management of IC have been complicated with emergence of newer species and resistance traits. C. tropicalis has already overtaken C. albicans in many Asian ICUs, while C. auris is rising rapidly worldwide. Recent genomic research has reclassified several yeasts into newer genera, and an updated version of MALDI-TOF MS or ITS sequencing is necessary for accurate identification. Having a knowledge of the differences in predisposing factors, epidemiology and susceptibility profile of already established pathogenic yeasts, as well as new emerging yeasts, are imperative for better patient management.

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A Case series of Wickerhamomyces anomalus: An emerging fungal pathogen and an entity of concern for neonatal intensive care unit

Cited by 4 publications

References 0 publications

Diagnosis and unsuccessful management of iatrogenic fungal septic arthritis caused byWickerhamomyces anomalous(formerlyCandida pelliculosa) and concurrent osteochondral lesion in Ireland

Diagnosis and unsuccessful management of iatrogenic fungal septic arthritis caused byWickerhamomyces anomalous(formerlyCandida pelliculosa) and concurrent osteochondral lesion in Ireland

Diagnosis and unsuccessful management of iatrogenic fungal septic arthritis caused by Wickerhamomyces anomalous (formerly Candida pelliculosa) and concurrent osteochondral lesion

Candidiasis and Other Emerging Yeasts

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