The Youth Guarantee (YG) is one of the most innovative European programs for young people. Given the complexity of the program for the analysis of its effectiveness and efficiency, it is necessary to provide clear information, supported by scientific evidence. This paper aims to examine the empirical evidence on the social outcomes of the YG program in the countries of Eastern Europe. The present analysis is based on a systematic review, a scientific method is effective for both decision-makers and the scientific community because the data they use and submit to the analysis are classified and evaluated based on scientific criteria, and objectives that allow obtaining a complete, up-to-date, and reliable images. The credibility of the investigated sources is ensured by including in the analysis only the reports published by the European institutions (European Commission, European Council, etc.) regarding YG. Through the analysis of these documents, we found that YG led to an increase in the employability rate of young people, their level of education, and social integration, to the development of self-confidence in their competencies but also in institutions (schools, PES, employers, etc.).