The digital processing of content resources has subverted the traditional paper content processing model and has also spread widely. The digital resources processed by text structure need to be structured and processed by professional knowledge, which can be saved as a professional digital content resource of knowledge base and provide basic metadata for intelligent knowledge service platform. The professional domain-based knowledge system construction system platform explored in this study is designed based on natural language processing. Natural language processing is an important branch of artificial intelligence, which is the application of artificial intelligence technology in linguistics. The system first extracts the professional thesaurus and domain ontology in the digital resources and then uses the new word discovery algorithm based on the label weight designed by artificial intelligence technology to intelligently extract and clean the new words of the basic thesaurus. At the same time, the relationship system between knowledge points and elements is established to realize the association extraction of targeted knowledge points, and finally the output content is enriched from knowledge points into related knowledge systems. In order to improve the scalability and universality of the system, the extended architecture of the thesaurus, algorithms, computational capabilities, tags, and exception thesaurus was taken into account when designing. At the same time, the implementation of “artificial intelligence [Formula: see text] manual assistance” was adopted. On the basis of improving the system availability, the experimental basis of the optimization algorithm is provided. The results of this research will bring an artificial intelligence innovation after the digitization to the publishing industry and will transform the content service into an intelligent service based on the knowledge system.