A case study of low-intensity focused ultrasound for treatment-resistant generalized anxiety disorder and major depressive disorder

Zielinski, Maggie; Mahdavi, Kennedy; Jordan, Sheldon E.; Haroon, Jonathan; Habelhah, Barshen; Beccera, Sergio; Spivak, Norman M.; Kuhn, Taylor; Bystrisky, Alexander

doi:10.1016/j.brs.2021.10.252

Cited by 4 publications

(1 citation statement)

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“…After FUS, the individual underwent another session of rTMS which resolved both the depression and anxiety. Thus, the authors hypothesized that FUS targeting the amygdala produces very specific symptom relief in anxiety, but not in depression and obsessive thinking [27].…”

Section: Major Depressionmentioning

confidence: 99%

The Prospect of Focal Ultrasound in the Treatment of Mental Disorders

Trenado,

Pedroarena-Leal,

Ruge

2023

Psychiatry International

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Mental disorders critically affect an individual’s quality of life by disrupting cognitive abilities and emotional states and are a major health burden worldwide. At present, psychotherapy and pharmacological interventions are the main approaches to target the symptoms associated with such disorders; however, some patients become treatment-resistant and thus, alternative treatments are needed. Focal ultrasound (FUS) is an emerging non-invasive therapeutic technology that relies on the use of sound waves to target brain regions with high specificity and without the need for incision or radiation. As a result, FUS has been proposed as a potential treatment for mental diseases as it may help to overcome several issues of current neuromodulation approaches. Here, we discuss basic neuroscience and clinical studies on the application of FUS and highlight perspectives and challenges of the technology as well as opportunities, for instance, regarding stimulation of deep brain structures with potential implication in modulating brain neuroplasticity of relevant cortical and subcortical pathways.

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Section: Major Depressionmentioning

confidence: 99%