A case study of nutrient intervention of oral precancerous lesions in India

Krishnaswamy, Kamala; Prasad, Mahendra; Krishna, T. Prasanna; Annapurna, V.; Reddy, G. A.

doi:10.1016/0964-1955(94)00027-2

Cited by 41 publications

(21 citation statements)

References 29 publications

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“…This modest experience is thus consistent with and corroborates reports from other groups that cite advantages of ''Antioxidant Therapy'' in treatment of leukoplakia [1,[27][28][29][30][31].…”

Section: Does Antioxidant Therapy Influence Lipid Peroxidase?supporting

confidence: 80%

Role of Measurement of Antioxidant Enzymes in Evaluation of Antioxidant Therapy in Tobacco Abusers with Oral Leukoplakia

Jain

Singh

et al. 2011

Indian J Otolaryngol Head Neck Surg

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Antioxidants are widely used in chemoprevention of malignancy. Numerous studies in medical literature have reported the evaluation of this treatment protocol by indirect methodology-epidemiology, invitro studies, pharmacology and animal models etc. However, there is a paucity of literature on the measurement of antioxidant enzymes as a parameter for assessing the outcome of antioxidant therapy. This study explores the efficacy and outcome of antioxidant enzyme assay in relation to antioxidant therapy in tobacco abusers, hitherto unreported in medical literature. A prospective cohort study with control in 50 patients carried out at a tertiary care teaching Institution (Institute of Medical Sciences, Banaras Hindu University, Varanasi, India). Out of these patients, 10 patients acted as control, rest 40 patients-all tobacco users in some form, were divided into three groups on the basis of histopathological grading of dysplasia-no dysplasia, mild or moderate dysplasia. The levels of Lipid peroxidase (LPO), Superoxide dismutase (SOD) and Catalase (CAT) in mucosa and serum were assayed in each group, and re-evaluated at the end of 3 months after intervention with antioxidant treatment. To detect any alteration in degree of dysplasia a repeat biopsy was also done at the end of 3 months. The results were statistically analysed using paired t test. A statistically significant decrease in level of LPO and SOD, and an increase in CAT levels were recorded both in mucosa and serum. However, no change in dysplasia and no new case of dysplasia were observed. Further, antioxidant treatment was continued for a year and the final out come of the lesion was assessed by ''Carter's criteria''. A final success rate of 74.19% was recorded in terms of partial or complete regression of the lesion. This study confirms the therapeutic efficacy of antioxidants in oral leukoplakia, and cites the importance of LPO, SOD and CAT in evaluating the efficacy of antioxidant treatment. However, the study failed to elucidate any relationship between enzyme measurement and the final outcome of the lesion.

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Section: Does Antioxidant Therapy Influence Lipid Peroxidase?supporting

confidence: 80%

Role of Measurement of Antioxidant Enzymes in Evaluation of Antioxidant Therapy in Tobacco Abusers with Oral Leukoplakia

Jain

Singh

et al. 2011

Indian J Otolaryngol Head Neck Surg

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“…Zn has important role in prevention of cancer formation by stabilizing the structure of deooxyribonucleic acid (DNA), ribonucleic acid (RNA) and ribosomes. Animal studies have shown that the administration of Zn may slow the progression of induced tumours and studies in humans also show that administration of Zn and other micronutrients may have therapeutic effects in patients with oral precancerous lesions [29]. Low serum Zn concentrations detected in some cancer such as esophageal carcinoma, ovarian cancer, cervical cancer [30,31].…”

Section: Discussionmentioning

confidence: 99%

Plasma Concentrations of Some Trace Element and Heavy Metals in Patients with Metastatic Colon Cancer

Özgür¹,

Demır²,

Doğan³

et al. 2013

JCT

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Purpose: It is well known that trace elements and heavy metals play a significant role in human health and disease. These elements play an important role in different metabolic pathways of cells and tissues. Trace element deficiency or excess is implicated in the development or progression of some cancers. We present a study which investigates serum/ plasma levels of trace-heavy elements in metastatic colon cancer patients and healthy subjects. Methods: Blood samples were collected from 29 healthy subjects and 40 patients with metastatic colon cancer in Oncology Department of Medical School of Yuzuncu Yil University. In both groups, the serum levels of copper (Cu), magnesium (Mg), lead (Pb), chromium (Cr), zinc (Zn) selenium (Se), manganese (Mn), and cadmium (Cd) were determined. Results: Higher levels of Cu, Mg, Pb, Cr, Zn, Mn and Cd were seen in patients with metastatic colon cancer compared to healthy subjects and these findings were statistically significant (p < 0.05). Se levels were noted to be lower in patients with colon cancer in comparison to healthy subjects and this finding was also statistically significant (p < 0.05). Conclusions: According to our findings there was significant diffence in trace elements and heavy metals levels between healthy subjects and metastatic colon cancer patients. Therefore heavy metal and trace elements may have prognostic significance in complex disorders including colon cancer. However, further comprehensive studies are needed in order to advance our understanding of the relationship between heavy metal and trace elements and their role in cancers.

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“…that can also be explained only if we accept the existence of PADS as it is detailed in our theoretical (epidemiological) paper. 41 Finally, it was reported earlier that many substances of PADS, namely ascorbic acid, 56,57 arginine, 58 2-deoxy-D-ribose, 59 mannose, 60 orotic acid, 61 pyridoxine, 62 riboflavin, 63 and tyrosine, 64 had antitumor effect when they were used singly. Taking our experimental findings into account that the above substances, moreover, could increase the effect of each other on tumor cells synergistically, [37][38][39][40] the above observations about the effect of the same substances singly strongly support the existence of the PADS and corroborate our results.…”

Section: Survival Time (Days)mentioning

confidence: 92%

Experimental Evidence for the Existence of the Passive Antitumor Defense System Formed by the Synergistic Action of Certain Small Substances of the Circulatory System

Kulcsár

2003

Cancer Biotherapy and Radiopharmaceuticals

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In AIDS, only a few types of tumors (mainly Kaposi's sarcoma and non-Hodgkin's lymphoma) increase in incidence despite global abnormalities in the immune system. In addition, the reason for the higher incidence of these tumors is not immunosuppression but other agents. This shows that the immune system has no absolute role in the prevention of tumors. Consequently, the fact that tumors do not develop in the majority of the population during their lifetime, indicates the existence of other defense system(s). We demonstrated previously that a mixture of 16 substances (selected experimentally out of 89 compounds of the circulatory system using the synergistic tumor cell-killing effect as criteria) had a cytotoxic effect (inducing apoptosis) in vitro and in vivo on tumor cell lines, but not on normal cells in vitro or animals. In our hypothesis these substances (L-tryptophan, L-tyrosine, L-methionine, L(-)malate, L-ascorbate, L-arginine, L-phenylalanine, L-histidine, 2-deoxy-D-ribose, d-biotin, pyridoxine, adenine, riboflavin, D(+)-mannose, orotate, and hippurate) are the active agents of a passive antitumor defense system (PADS). On the basis of the results, a tablet and a cream were developed, and an infusion is in preclinical phase. In this study we demonstrate that the above-mentioned substances can kill tumor cells when the experimental protocols, concentrations, and cell numbers are chosen to be comparable to the physiological conditions that exist in the living system when these substances fight against arising cancer cells. The results of our experiments demonstrate that the PADS really works in the human body.

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A case study of nutrient intervention of oral precancerous lesions in India

Cited by 41 publications

References 29 publications

Role of Measurement of Antioxidant Enzymes in Evaluation of Antioxidant Therapy in Tobacco Abusers with Oral Leukoplakia

Role of Measurement of Antioxidant Enzymes in Evaluation of Antioxidant Therapy in Tobacco Abusers with Oral Leukoplakia

Plasma Concentrations of Some Trace Element and Heavy Metals in Patients with Metastatic Colon Cancer

Experimental Evidence for the Existence of the Passive Antitumor Defense System Formed by the Synergistic Action of Certain Small Substances of the Circulatory System

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