Background: Advocacy is a core component of medical professionalism. Medical organizations frequently emphasize advocacy, particularly around just resource distribution and social determinants of health, but it is unclear how educators can best prepare trainees for this professional obligation. Objective: We sought to assess medical students’ attitudes toward advocacy, including activities and issues of interest, and to determine congruence with professional obligations.Design, Participants, and Measures: A cross-sectional, web-based survey probed U.S. medical students’ attitudes toward advocacy around 7 issues directly related to health (e.g. nutrition/obesity, addiction) and 11 indirect determinants of health (e.g. housing, transportation, education). Descriptive statistics, Kruskal-Wallis tests, and regression analysis investigated associations with gender, race, political identification, and intended future field.Key Results: Of 240 students completing the survey, 53% were female; most were white (62%) or Asian (28%). Clinical/non-primary-care was the most common intended future field (61%). Most agreed it is very important that physicians encourage medical organizations to advocate for public health (76%) and provide health-related expertise to the community (57%). More participants rated advocacy for medical issues as very important (e.g. drug addiction [83%], nutrition [81%]), compared to issues with indirect connections to health (e.g. national security [22%], transportation [36%], criminal justice [40%]) (p<0.001). Generally, liberals and non-whites were more likely than others to value advocacy. Conclusions: Medical students reported strong interest in advocacy, particularly around health issues, consistent with professional standards. Many attitudes were associated with political affiliation and race. To optimize future physician advocacy, educators should provide opportunities for learning and engagement in issues of interest.