Background: The response of the human lungs to exposure to various particles like seen in atmospheric pollution, work place, various gases, have been studied in different populations by various studies. The pollution level in Chennai city is moderate whereas it is quite high in the suburbs of Chennai. Aim: To understand the effect of petrol and diesel vapours on lungs in persons working at petrol pump stations in the suburbs of Chennai through Spirometry. Methods: This study was conducted at 20 Petrol pumps in the suburbs of Chennai. Total participants were 250. Of these, 123 were workers [Group I] and 127 were office employees working in the pump stations [Group II]. Spirometry was successfully performed on 102 workers [GroupI] and on 102 office employees [Group II] who were also used as healthy controls. Result: The Spirometry values were significantly reduced in participants working in the petrol pumps as compared to the controls. The reduction further increased with prolonged duration of exposure. Conclusion: This study concludes that the respiratory function declines in those persons working in petrol pumps due to constant exposure to petrol and diesel fumes and the degree of impairment increases with the duration of exposure.