Hand-foot-and-mouth disease is a common childhood illness caused by enteroviruses. Blood tests may be affected in hand foot and mouth disease.The aim of this study is to compare the demographic and laboratory data of the patients who applied with hand, foot and mouth disease with the healthy child group and to determine the effect of the disease on the laboratory values. This study was done retrospectively. The research was conducted with 94 children. 47 children with hand, foot and mouth disease constituted the experimental group and 47 children admitted to the hospital for other reasons constituted the control group. All of the children in the experimental group had a rash. The White Blood Cell (WBC) and direct bilirubin levels of the children in the experimental group were higher than those of the control group (p