A catalytic multistage fixed-bed tower bioreactor in an industrial-scale pilot plant for alcohol production

Aroma formation by immobilized yeast cells in fermentation processes

“…Another approach to the design of a packed bed is a multi‐stage bed, in which the biocatalyst is divided into several sections. It has been used in a horizontal fermentor containing five replaceable immobilized plates (Ogbonna et al, ), or a vertical one containing kissiris (Bakoyianis and Koutinas, ; Koutinas et al, ), gluten pellets (Sipsas et al, ), glass beads (Shindo et al, ), zeolite (Shindo et al, ) or hydrogel beads (Manojlovic et al, ) as a support for the yeast. Such a bioreactor design is considered advantageous over typical packed‐bed configurations, as the pressures to which the biocatalyst is exposed are dramatically reduced, and thus its destruction is avoided.…”

Effect of fermentation conditions and immobilization supports on the wine making

“…Finally, continuous process is favored due to efficient monitoring of the process. The experience that has been acquired enables proposition of a relatively small (5000-10,000 L) ''Multi Stage Fixed Bed Tower'' (MFBT) bioreactor (Bakoyianis & Koutinas, 1996;Koutinas, Bakoyianis, Argiriou, Kanellaki, & Voliotis, 1997;Loukatos et al, 2000) that could be used for industrialization of immobilized cells for wine making, as handling of the above supports at this scale could be performed without any problems.…”

Low-cost microbioreactor for high-throughput bioprocessing

“…Additionally, bioprocesses are important in a wide variety of industries besides pharmaceuticals-food industry, ecology, water treatment, etc. (Arroyo et al, 2000;Bakoyianis and Koutinas, 1996;Bylund et al, 2000;Handa-Corrigan et al, 2000;López-López et al, 1999;McIntyre et al, 1999;Pressman et al, 1999;Yang et al, 2000). For bioprocess optimization in the pharmaceutical industry, significant numbers of fermentations are needed under varying environmental and nutritional conditions.…”