A cation exchange method for separation of 111In from inactive silver, copper, traces of iron and radioactive gallium and zinc isotopes

Das, Manab Kumar; Chattopadhayay, Sankha; Sarkar, B. R.; Ramamoorthy, N.

doi:10.1016/s0969-8043(96)00123-6

Cited by 17 publications

(7 citation statements)

References 9 publications

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“…The production of 111 In is well-established and can be achieved directly via nat Cd(d,xn), nat Cd(p,xn), nat Cd(α,x), nat Ag(α,xn), nat Ag( 7 Li,x), or nat Ag( 11 B,x) or indirectly by nat Rh( 12 C, x) 111 Sb → 111 Sn → 111 In, nat Sn(n,x) 111 Sn → 111 In, or nat Sn(p,x) 111 Sn → 111 In. − The most common production methods are proton or deuteron bombardment of natural or enriched cadmium targets or α bombardment of silver targets. These methods are popular because they can achieve high yields of nca 111 In while avoiding or minimizing the production of the long-lived contaminant 114m In ( t 1/2 = 1188 h).…”

Section: Indiummentioning

confidence: 99%

Radioactive Main Group and Rare Earth Metals for Imaging and Therapy

2018

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Radiometals possess an exceptional breadth of decay properties and have been applied to medicine with great success for several decades. The majority of current clinical use involves diagnostic procedures, which use either positron-emission tomography (PET) or single-photon imaging to detect anatomic abnormalities that are difficult to visualize using conventional imaging techniques (e.g., MRI and X-ray). The potential of therapeutic radiometals has more recently been realized and relies on ionizing radiation to induce irreversible DNA damage, resulting in cell death. In both cases, radiopharmaceutical development has been largely geared toward the field of oncology; thus, selective tumor targeting is often essential for efficacious drug use. To this end, the rational design of fourcomponent radiopharmaceuticals has become popularized. This Review introduces fundamental concepts of drug design and applications, with particular emphasis on bifunctional chelators (BFCs), which ensure secure consolidation of the radiometal and targeting vector and are integral for optimal drug performance. Also presented are detailed accounts of production, chelation chemistry, and biological use of selected main group and rare earth radiometals.

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Section: Indiummentioning

confidence: 99%

Radioactive Main Group and Rare Earth Metals for Imaging and Therapy

2018

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“…Alternatively, 111 In is also produced by irradiation of a natural silver target with an energetic a-beam in a cyclotron according to the 109 Ag(a,2n) 111 In reaction. [33][34][35][36] Radiochemical separation of 111 In from the irradiated target can be performed using a large variety of techniques, such as coprecipitation with Fe(OH) 3 or La(OH) 3 , ion exchange, and extraction chromatography. Each of the techniques has its own advantages and disadvantages.…”

Section: Production Of Radionuclides Currently Used In Prrtmentioning

confidence: 99%

“…Liquidliquid extraction and ion-exchange chromatography (IEC) are widely used for radiochemical separation of 111 In on the commercial scale. 31,32,[35][36][37][38][39] However, despite the development of robust separation and purification technology, low production yields are a major impediment in the large-scale production of 111 In required for its therapeutic use.…”

Section: Production Of Radionuclides Currently Used In Prrtmentioning

confidence: 99%

Peptide Receptor Radionuclide Therapy: An Overview

Dash

Chakraborty

Pillai³

et al. 2015

Cancer Biotherapy and Radiopharmaceuticals

102

101

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Peptide receptor radionuclide therapy (PRRT) is a site-directed targeted therapeutic strategy that specifically uses radiolabeled peptides as biological targeting vectors designed to deliver cytotoxic levels of radiation dose to cancer cells, which overexpress specific receptors. Interest in PRRT has steadily grown because of the advantages of targeting cellular receptors in vivo with high sensitivity as well as specificity and treatment at the molecular level. Recent advances in molecular biology have not only stimulated advances in PRRT in a sustainable manner but have also pushed the field significantly forward to several unexplored possibilities. Recent decades have witnessed unprecedented endeavors for developing radiolabeled receptor-binding somatostatin analogs for the treatment of neuroendocrine tumors, which have played an important role in the evolution of PRRT and paved the way for the development of other receptor-targeting peptides. Several peptides targeting a variety of receptors have been identified, demonstrating their potential to catalyze breakthroughs in PRRT. In this review, the authors discuss several of these peptides and their analogs with regard to their applications and potential in radionuclide therapy. The advancement in the availability of combinatorial peptide libraries for peptide designing and screening provides the capability of regulating immunogenicity and chemical manipulability. Moreover, the availability of a wide range of bifunctional chelating agents opens up the scope of convenient radiolabeling. For these reasons, it would be possible to envision a future where the scope of PRRT can be tailored for patient-specific application. While PRRT lies at the interface between many disciplines, this technology is inextricably linked to the availability of the therapeutic radionuclides of required quality and activity levels and hence their production is also reviewed.

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“…Stock solutions containing 1000 mg L -1 from cadmium and copper were prepared by dissolution of 1.631 g of CdCl 2 or 2.73 g of CuCl 2 .2H 2 O in 1000 mL measuring flask using double distilled water. Separation experiments: Separation of radioindium from Cd and copper ions was carried out using different cation exchangers at room temperature.…”

Section: Methodsmentioning

confidence: 99%

“…A chromatography method using inorganic exchange and organic exchange Doex and Amberlit was described [2]. Sorption of 111 …”

Section: Introductionmentioning

confidence: 99%

Separation of Cyclotron Produced In-111 (III) from Cadmium (II) and Copper (II) Ions Using Ion Exchange Technique in Different Media

Ha¹,

M²

2016

Chem Sci J

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The commercial cation exchangers TSKgel BioAssist S, TSKgel CM-2SW and TSKgel CM-STAT have been used for the separation of 111 In (III) from Cd (II) and Cu (II) ions. The separation was carried out using low cost cation exchangers based on the differences in the sorption affinity of In, Cu and Cd towards the ion exchanger from 0.01 mol L -1 HCl. The effects of various parameters such as shaking time, HCl concentration and acetate buffer concentration were examined. A comparative study between cation exchangers showed the best one for radiochemical separation yielded more than 98% within 50 min by using column study.Conventional techniques were reported for separation of In-111 from Cd target using different types of cation exchangers [7], and synthetic polymeric resins [8]. A chromatographic method using inorganic ion exchanger (zirconium oxide) for radiochemical separation of non-carrier added In-115 from Cd-115 over a column of zirconium oxide was described [9]. Recently, numerous alternative techniques have been examined for the separation of indium from cadmium and copper using silica extracted agricultural wastes. Column separation technique is widely applied to separate 111 In from interfering ions based on the evaluation of distribution coefficient K d .Modern separation techniques for separation of Ga(II) using poly(acrylamide-acrylic acid disodium EDTA) were studied. The prepared inorganic ion exchangers used separation of radioactive elements such as cesium [10].In the present work we investigated the possibility of using cation exchangers for separation of radioindium from cadmium and copper, the distribution coefficients of the three elements on different types of cation exchangers were measured in 0.01 M HCl, acetate buffer at pH 4 and EDTA (10 -3 M) to find the best conditions for separation. Materials and Methods MaterialsIndium metal (99.9% purity,), anhydrous cadmium chloride (CdCl 2 ), cupric chloride dehydrate (CuCl 2 .2H 2 O), sodium hydroxide (NaOH), anhydrous sodium acetate (CH 3 COONa), Diethylene Tetramine Penta Acetic acid (DTPA), and Ethylene Diamine Tetra Acetic acid (EDTA) were reagent grade chemicals and supplied by Merck (Darmstadt, Germany). Chemical Sciences JournalChem ic a l S cience s J o u rnal

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A cation exchange method for separation of 111In from inactive silver, copper, traces of iron and radioactive gallium and zinc isotopes

Cited by 17 publications

References 9 publications

Radioactive Main Group and Rare Earth Metals for Imaging and Therapy

Radioactive Main Group and Rare Earth Metals for Imaging and Therapy

Peptide Receptor Radionuclide Therapy: An Overview

Separation of Cyclotron Produced In-111 (III) from Cadmium (II) and Copper (II) Ions Using Ion Exchange Technique in Different Media

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