Medication errors happen all over the world and can cause people real harm. To solve this problem, it is important to know what healthcare workers know, how they feel about medication errors, and what they do about them. The goal of this systematic review of the literature is to find and summarize the current data about the KAP of healthcare workers toward medication errors and related factors. Electronic sources like PubMed, Scopus, and Web of Science were thoroughly searched for applicable studies released between January 2013 and December 2023. There were a total of 31 studies looked at in this study. The results showed that healthcare workers have a middling amount of knowledge about medication errors, but this varies from country to country and specialty to specialty. Most people did not like the idea of medication errors, and the biggest reason they didn't tell them was fear of being sued. Doctors and nurses not following safety rules and not communicating to each other well enough often cause medication errors. Too much work, stress, and not enough training also is affected by medication safety habits. The results of this study show that to reduce the number of medication errors there needs to be more education, better communication and teamwork among healthcare workers, and the creation of processes that put medication safety first.