A causal role of anterior prefrontal-putamen circuit for response inhibition revealed by transcranial ultrasound stimulation in humans

Nakajima, Koji; Osada, Takahiro; Ogawa, Akitoshi; Tanaka, Masaki; Oka, Satoshi; Kamagata, Koji; Aoki, Shigeki; Oshima, Yasushi; Tanaka, Sakae; Konishi, Seiki

doi:10.1016/j.celrep.2022.111197

Cited by 43 publications

(34 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Building on these results, the current challenge is to develop efficacious neuromodulatory protocols with minimal auditory interference. Efforts in this direction are already underway (Mohammadjavadi et al, 2019; Nakajima et al, 2022; Zeng et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

“…Accordingly, in light with the abundant evidence from controlled systems, one could argue that the TUS dose in the present study could have been insufficient to evoke direct neuromodulation. Indeed, despite the applied intensities exceeding prior relevant human work (Fomenko et al, 2020; Legon, Bansal, et al, 2018; Xia et al, 2021) the total applied neuromodulatory doses are relatively low as compared to, for example, repetitive TUS protocols (rTUS) in animal work (Folloni et al, 2019; Verhagen et al, 2019) or recent human studies (Nakajima et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Auditory confounds can drive online effects of transcranial ultrasonic stimulation in humans

Kop

Oghli

Grippe

et al. 2023

Preprint

View full text Add to dashboard Cite

Transcranial ultrasonic stimulation (TUS) is rapidly emerging as a promising non-invasive neuromodulation technique. TUS is already well-established in animal models, and now stimulation protocols that optimize neuromodulatory efficacy for human application are required. One promising protocol, pulsed at 1000 Hz, has consistently resulted in motor cortical inhibition. At the same time, a parallel research line has highlighted the potentially confounding influence of peripheral auditory stimulation arising from pulsing TUS at audible frequencies. Across four experiments, one preregistered, at three independent institutions, we employed tightly matched control conditions to disentangle direct neuromodulatory effects of TUS from those driven by the salient auditory confound in a combined transcranial ultrasonic and magnetic stimulation paradigm. We replicated motor cortical inhibition following TUS, but showed through both controls and manipulation of stimulation intensity, duration, and auditory masking conditions that this inhibition was driven by peripheral auditory stimulation rather than direct neuromodulation. This study highlights the substantial impact of the auditory confound, invites a reevaluation of prior findings, and calls for appropriate control conditions in future TUS work. Only when direct effects are disentangled from those driven by peripheral confounds can TUS fully realize its potential for neuroscientific research and clinical applications.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Auditory confounds can drive online effects of transcranial ultrasonic stimulation in humans

Kop

Oghli

Grippe

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…The total on-state duration of TUS is 8 s in the two protocols, and no subjects reported any adverse effects throughout the experiments of both the protocols. In [45], LTDlike plasticity in human left M1was induced by a 40 s train of pulsed TUS (I SPPA = 30.0 W cm −2 , I SPTA = 9.0 W cm −2 , in total 12 s on-state duration) with no adverse effects after the TUS experiments. Though these results together support that the 15 min rTUS protocol used in this study would be safe, more studies are needed to further accumulate safety evidence.…”

Section: Safety Issuesmentioning

confidence: 95%

“…On the other side, Nakajima et al showed that a 40 s train of pulsed TUS could induce LTD-like plasticity (i.e. long-lasting suppressed MEP) in human left M1 [45]. These results suggest that the LTP/LTD-like plasticity induced by TUS is dependent on the acoustic parameters.…”

Section: Introductionmentioning

confidence: 99%

Transcranial ultrasound stimulation modulates the interhemispheric balance of excitability in human motor cortex

et al. 2023

View full text Add to dashboard Cite

Background: Low-intensity transcranial ultrasound stimulation (TUS) could induce both immediate and long-lasting neuromodulatory effects in human brains. Interhemispheric imbalance at prefrontal or motor cortices generally associates with various cognitive decline in aging and mental disorders. However, whether TUS could modulate the interhemispheric balance of excitability in human brain remains unknown. Objective: This study aims to explore whether repetitive TUS (rTUS) intervention can modulate the interhemispheric balance of excitability between bilateral motor cortex (M1) in healthy subjects. Methods: Motor evoked potentials (MEPs) at bilateral M1 were measured at 15min and 0min before a 15 min active or sham rTUS intervention on left M1 and at 0min, 15min and 30min after the intervention, and the Chinese version of brief neurocognitive test battery (C-BCT) was conducted before and after the intervention respectively. Cortical excitability was quantified by MEPs, and the long-lasting changes of MEP amplitude was used as an index of plasticity. Results: In the active rTUS group (n=20), the ipsilateral MEP amplitude increased significantly compared with baselines and lasted for up to 30 min after intervention, while the contralateral MEP amplitude decreased lasting for 15 min, yielding increased laterality between bilateral MEPs. Furthermore, rTUS intervention induced changes in some C-BCT scores, and the changes of scores correlated with the changes of MEP amplitudes induced by rTUS intervention. The sham rTUS group (n=20) showed no significant changes in MEPs and C-BCT scores. In addition, no participants reported any adverse effects during and after the rTUS intervention, and no obvious temperature increase appeared in skull or brain tissues in simulation. Conclusions: rTUS intervention modulated the plasticity of ipsilateral M1 and the interhemispheric balance of M1 excitability in human brain, and improved cognitive performance, suggesting a considerable potential of rTUS in clinical interventions.

show abstract

“…224 This multimodal approach contributed to the understanding of both the parameter setting of TUS neuromodulation toward cortical and subcortical regions and the interconnections of deep brain structures to cortical regions. 224 improving motor functions and task-related results following ultrasonic therapy to the thalamus. 240 It becomes clear that TUS has excellent properties for targeting deep brain regions, perhaps even combinable and applicable in DBS patients and beyond.…”

Section: Spinal Cord Stimulation (Scs)mentioning

confidence: 99%

Low-Intensity Focused Ultrasound Neuromodulation for Stroke Recovery: A Novel Deep Brain Stimulation Approach for Neurorehabilitation?

Yüksel

Sun

Latchoumane

et al. 2023

IEEE Open J. Eng. Med. Biol.

View full text Add to dashboard Cite

Stroke as the leading cause of adult long-term disability and has a significant impact on patients, society and socio-economics. Non-invasive brain stimulation (NIBS) approaches such as transcranial magnetic stimulation (TMS) or transcranial electrical stimulation (tES) are considered as potential therapeutic options to enhance functional reorganization and augment the effects of neurorehabilitation. However, non-invasive electrical and magnetic stimulation paradigms are limited by their depth focality trade-off function that does not allow to target deep key brain structures critically important for recovery processes. Transcranial ultrasound stimulation (TUS) is an emerging approach for non-invasive deep brain neuromodulation. Using non-ionizing, ultrasonic waves with millimeter-accuracy spatial resolution, excellent steering capacity and long penetration depth, TUS has the potential to serve as a novel non-invasive deep brain stimulation method to establish unprecedented neuromodulation and novel neurorehabilitation protocols. The purpose of the present review is to provide an overview on the current knowledge about the neuromodulatory effects of TUS while discussing the potential of TUS in the field of stroke recovery, with respect to existing NIBS methods. We will address and discuss critically crucial open questions and remaining challenges that need to be addressed before establishing TUS as a new clinical neurorehabilitation approach for motor stroke recovery.

show abstract

A causal role of anterior prefrontal-putamen circuit for response inhibition revealed by transcranial ultrasound stimulation in humans

Cited by 43 publications

References 97 publications

Auditory confounds can drive online effects of transcranial ultrasonic stimulation in humans

Auditory confounds can drive online effects of transcranial ultrasonic stimulation in humans

Transcranial ultrasound stimulation modulates the interhemispheric balance of excitability in human motor cortex

Low-Intensity Focused Ultrasound Neuromodulation for Stroke Recovery: A Novel Deep Brain Stimulation Approach for Neurorehabilitation?

Contact Info

Product

Resources

About