A Cell Manipulation Method Based on Stagnation Point of Swirl

Ou, Zhiming; Zhang, Qin; Yang, Hao

doi:10.1007/978-3-030-27526-6_14

Cited by 2 publications

(1 citation statement)

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“…Thus, we constructed a three-tube swirl, and numerically demonstrated that the cell can be transported along with different directions by matching the jet velocities of three microtubules. 28) In this paper, we further analyze the pressure, velocity and vorticity distribution of three-tube swirl, and discuss the mechanism of cell manipulation based on swirl. Moreover, we experimentally demonstrate the feasibility of this approach and extend the application to manipulate multiple cells.…”

Section: Introductionmentioning

confidence: 99%

Method and experimental study of cell manipulation based on swirl

Zhang

et al. 2021

Jpn. J. Appl. Phys.

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The development of a multifunctional noncontact manipulation method is desired in cell manipulation. In this paper, we theoretically study and experimentally demonstrate the method of cell manipulation based on swirl. We analyze the swirl flow field features and the cell manipulation mechanism. The swirl is constructed by jetting fluid through three microtubules, and the cells are manipulated using the low pressure of stagnation point and the constant vorticity in the flow field. The experimental results indicate that the cell can be trapped robustly using the stagnation point of swirl. Moreover, the cell rotates with the same angular velocity at any position of the swirl flow field, and the cell is transported along with the movement of the stagnation point. Finally, we extend the application of swirl to manipulate multiple cells. Overall, this method can achieve trapping, rotating, transporting, pairing and enriching for cells, which realizes multifunctional cell manipulation.

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Section: Introductionmentioning

confidence: 99%