A cellular cardiac matrix-based porous microcarrier as a cell delivery system in myocardial tissue engineering application

Asl, Sasan Ghanbari; Mashayekhan, Shohreh; Khanmohammadi, Mehdi

doi:10.1007/s13726-022-01059-3

Cited by 3 publications

(1 citation statement)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…75 To address these limitations, exploiting suitable scaffolds is an effective strategy to shelter the stem cells and enhance their survival while controlling their fate. 77 Among different types of reported scaffolds, hydrogel-based biomaterials represent one of the most promising candidates for stem cell transplantation due to their capacity of retaining the cells in the infarcted site within a biomimetic microenvironment. 78 This section focuses on in-situ forming injectable dECM-based hydrogels as a minimally invasive treatment for the regeneration and repair of cardiac tissue.…”

Section: Decm In Regenerative Medicinementioning

confidence: 99%

Recent advances in soluble decellularized extracellular matrix for heart tissue engineering and organ modeling

Kafili,

Kabir,

Jalali Kandeloos

et al. 2023

J Biomater Appl

Self Cite

View full text Add to dashboard Cite

Despite the advent of tissue engineering (TE) for the remodeling, restoring, and replacing damaged cardiovascular tissues, the progress is hindered by the optimal mechanical and chemical properties required to induce cardiac tissue-specific cellular behaviors including migration, adhesion, proliferation, and differentiation. Cardiac extracellular matrix (ECM) consists of numerous structural and functional molecules and tissue-specific cells, therefore it plays an important role in stimulating cell proliferation and differentiation, guiding cell migration, and activating regulatory signaling pathways. With the improvement and modification of cell removal methods, decellularized ECM (dECM) preserves biochemical complexity, and bio-inductive properties of the native matrix and improves the process of generating functional tissue. In this review, we first provide an overview of the latest advancements in the utilization of dECM in in vitro model systems for disease and tissue modeling, as well as drug screening. Then, we explore the role of dECM-based biomaterials in cardiovascular regenerative medicine (RM), including both invasive and non-invasive methods. In the next step, we elucidate the engineering and material considerations in the preparation of dECM-based biomaterials, namely various decellularization techniques, dECM sources, modulation, characterizations, and fabrication approaches. Finally, we discuss the limitations and future directions in fabrication of dECM-based biomaterials for cardiovascular modeling, RM, and clinical translation.

show abstract

Section: Decm In Regenerative Medicinementioning

confidence: 99%