A cellulose/β-cyclodextrin nanofiber patch as a wearable epidermal glucose sensor

Kim, Kyu Oh; Kim, Geon Jin; Kim, Ji Hye

doi:10.1039/c9ra03887f

Cited by 39 publications

(26 citation statements)

References 21 publications

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“…The use of cellulose-based scaffolds in diagnostic and biosensing has recently gained more attention. Kim et al [219] evaluated the potential use of a cellulose-based patch for non-invasive monitoring of interstitial fluid (ISF) glucose levels. The authors used electrospun cellulose/β-cyclodextrin (β-CD), which immobilised the GOx enzyme that can detect the epidermal glucose level.…”

Section: Future Prospect and Applications Of Micro-and Nanocellulose-mentioning

confidence: 99%

A Review on Micro- to Nanocellulose Biopolymer Scaffold Forming for Tissue Engineering Applications

et al. 2020

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Biopolymers have been used as a replacement material for synthetic polymers in scaffold forming due to its biocompatibility and nontoxic properties. Production of scaffold for tissue repair is a major part of tissue engineering. Tissue engineering techniques for scaffold forming with cellulose-based material is at the forefront of present-day research. Micro- and nanocellulose-based materials are at the forefront of scientific development in the areas of biomedical engineering. Cellulose in scaffold forming has attracted a lot of attention because of its availability and toxicity properties. The discovery of nanocellulose has further improved the usability of cellulose as a reinforcement in biopolymers intended for scaffold fabrication. Its unique physical, chemical, mechanical, and biological properties offer some important advantages over synthetic polymer materials. This review presents a critical overview of micro- and nanoscale cellulose-based materials used for scaffold preparation. It also analyses the relationship between the method of fabrication and properties of the fabricated scaffold. The review concludes with future potential research on cellulose micro- and nano-based scaffolds. The review provides an up-to-date summary of the status and future prospective applications of micro- and nanocellulose-based scaffolds for tissue engineering.

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Section: Future Prospect and Applications Of Micro-and Nanocellulose-mentioning

confidence: 99%

A Review on Micro- to Nanocellulose Biopolymer Scaffold Forming for Tissue Engineering Applications

et al. 2020

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“…As shown, there are four kinds of carbon atoms in different functional groups, such as ring carbons (C–C) at ~ 284.6–284.8 eV, carbons in phenolic hydroxyl groups (C–OH/C–N) at 286.0 eV, carbons in epoxy/ether (C–O–C) at 287.0 eV, and carboxylic carbons (O–C=O) at 289.0 eV. The peaks of the C–OH/C–N of (d) and (e) are obviously higher than those of (a), (b), and (c), which indicates that these glucose oxidases in (d) and (e) are stably immobilized into the β-CD cavities 26 . In particular, the NF-containing AuNPs were more evidently verified.…”

Section: Resultsmentioning

confidence: 92%

Novel glucose-responsive of the transparent nanofiber hydrogel patches as a wearable biosensor via electrospinning

Kim

2020

Sci Rep

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Micro- and nanofiber (NF) hydrogels fabricated by electrospinning to typically exhibit outstanding high porosity and specific surface area under hydrated conditions. However, the high crystallinity of NFs limits the achievement of transparency via electrospinning. Transparent poly(vinyl alcohol)/β-cyclodextrin polymer NF hydrogels contacted with reverse iontophoresis electrodes were prepared for the development of a non-invasive continuous monitoring biosensor platform of interstitial fluid glucose levels reaching ~ 1 mM. We designed the PVA/BTCA/β-CD/GOx/AuNPs NF hydrogels, which exhibit flexibility, biocompatibility, excellent absorptivity (DI water: 21.9 ± 1.9, PBS: 41.91 ± 3.4), good mechanical properties (dried: 12.1 MPa, wetted: 5.33 MPa), and high enzyme activity of 76.3%. Owing to the unique features of PVA/β-CD/GOx containing AuNPs NF hydrogels, such as high permeability to bio-substrates and rapid electron transfer, our biosensors demonstrate excellent sensing performance with a wide linear range, high sensitivity(47.2 μA mM−1), low sensing limit (0.01 mM), and rapid response time (< 15 s). The results indicate that the PVA/BTCA/β-CD/GOx/AuNPs NF hydrogel patch sensor can measure the glucose concentration in human serum and holds massive potential for future clinical applications.

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“…Cellulose hydrogels may also be designed for chemical sensing. For example, Kim et al [ 82 ] described a cellulose/β-cyclodextrin nanofiber patch as a wearable skin glucose sensor where glucose oxidase enzymes were entrapped into a cellulose/β-cyclodextrin electrospun membrane. Detection was based on reverse iontophoresis of interstitial fluid through the skin, to monitor glucose levels between 1 μM and 1 mM, with a sensitivity of about 5 μA·mM −1 .…”

Section: Discussionmentioning

confidence: 99%

Sensors Made of Natural Renewable Materials: Efficiency, Recyclability or Biodegradability—The Green Electronics

Piro

Tran

Thu

2020

Sensors

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Nowadays, sensor devices are developing fast. It is therefore critical, at a time when the availability and recyclability of materials are, along with acceptability from the consumers, among the most important criteria used by industrials before pushing a device to market, to review the most recent advances related to functional electronic materials, substrates or packaging materials with natural origins and/or presenting good recyclability. This review proposes, in the first section, passive materials used as substrates, supporting matrixes or packaging, whether organic or inorganic, then active materials such as conductors or semiconductors. The last section is dedicated to the review of pertinent sensors and devices integrated in sensors, along with their fabrication methods.

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A cellulose/β-cyclodextrin nanofiber patch as a wearable epidermal glucose sensor

Abstract: In this study, we aimed to develop a cellulose/β-cyclodextrin (β-CD) electrospun immobilized GOx enzyme patch with reverse iontophoresis for noninvasive monitoring of interstitial fluid (ISF) glucose levels (0.1–0.6 mM dm−3).

Cited by 39 publications

References 21 publications

A Review on Micro- to Nanocellulose Biopolymer Scaffold Forming for Tissue Engineering Applications

A Review on Micro- to Nanocellulose Biopolymer Scaffold Forming for Tissue Engineering Applications

Novel glucose-responsive of the transparent nanofiber hydrogel patches as a wearable biosensor via electrospinning

Sensors Made of Natural Renewable Materials: Efficiency, Recyclability or Biodegradability—The Green Electronics

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