A central giant cell granuloma in posterior part of maxilla—A case report

Garg, Priyanka; Jain, Jinendra; De, Nayana; Chatterjee, Kushal

doi:10.1016/j.ijscr.2016.11.015

Cited by 21 publications

(23 citation statements)

References 8 publications

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“…It can be present in patients from age of 2 years above. But most cases are seen between 20 to 40 years of age [1,5]. Females are affected slightly more than males, the reason for this is thought to be because of hormonal factors despite the fact that lesions rarely express estrogen receptors [6,10].…”

Section: Resultsmentioning

confidence: 99%

Radiological features of Central Giant Cell Granuloma: Comparative study of 7 case reports and literature review

Shrestha

Zhang

Jing

et al. 2020

Preprint

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Background: To review and analyze the clinical and imaging features of central giant cell granuloma patients and to review the relevant literatures for the diagnosis and clinical manifestation of central giant cell granuloma.Methods: 7 cases of central giant cell granuloma were retrospectively selected for the study all of which were confirmed by pathology and had relevant imaging investigations. All 7 cases had undergone CT scan, 3 cases had undergone MRI scan. Detailed clinical features were compared along with the imaging findings and analysis was done on the basis of their presentation and imaging features.Results: The clinical features, radiologic features were varied according to the site of the lesion. CT features include unevenly dense expansile mass causing bone destruction and cortical thinning. While MRI features with low to iso-intensity in T1 weighted and T2 weighted images. There may be presence of cystic degeneration, hemorrhage or hemosiderin deposits or osteoid formation, which can cause T1 and T2 signal changes. On contrast study, the lesion doesn’t enhance but periphery may enhance mildly. Conclusion: Unevenly dense expansile mass with bone destruction and cortical thinning with low to iso-intensity in T1 weighted and T2 weighted images and mildly enhance peripherally, CGCG should be considered.

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Section: Resultsmentioning

confidence: 99%

Radiological features of Central Giant Cell Granuloma: Comparative study of 7 case reports and literature review

Shrestha

Zhang

Jing

et al. 2020

Preprint

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“…Since microscopically the first 3 resemble each other astoundingly (9), a complete clinical examination, medical history, and both biochemical and radiologic investigations are essential for diagnosis and should be mandatory practice. A comparison of the typical findings of these 3 conditions is presented in Table 1 (1)(2)(3)(8)(9)(10)(11)(12). Apart from the characteristic calcium-phosphorus-PTH biochemical profile, one main difference is that in brown tumors the periosteum is usually eroded, whereas in central giant cell granulomas and giant cell tumors of the bone it is usually intact or expanded.…”

Section: Discussionmentioning

confidence: 99%

“…Central giant cell granuloma is a non-odontogenic, localized, benign, although sometimes aggressively osteolytic, fibrous proliferation that results in bone lysis and reactive bone formation (11). It is has a predilection for the maxilla and the mandible, while location in other bones is rare (8).…”

Section: Discussionmentioning

confidence: 99%

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Mandibular Brown Tumor as Atypical Presentation of Primary Hyperparathyroidism: two Case Reports And Literature Review

Noriega-Jalil

Valverde-García

García-Barajas

et al. 2018

AACE Clinical Case Reports

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Objective: We report 2 cases of patients who developed solitary, aggressive mandibular tumors. The tumors were surgically removed due to suspected malignancy, and their histopathologic diagnoses were central giant cell granuloma and giant cell bone tumor in patients with undiagnosed primary hyperparathyroidism (PHPT). Methods: We present 2 case reports and a review of the literature. Results: Both cases were single, mandibular tumors with aggressive, expansive, and rapidly evolving behavior. In both cases, a malignant tumor process was suspected and the lesion was surgically resected. The histopathologic diagnosis was giant cell bone tumor in one and central giant cell granuloma in the other. Several months later, each was sent to the endocrinology service for hypercalcemia. One of them presented hypercalcemic crisis and pancreatitis and the other had a fractured humerus. The diagnosis of PHPT was made by demonstrating hypercalcemia and elevated parathyroid hormone levels in biochemical studies. The review of the histopathologic study in both cases concluded mandibular brown tumor in the biochemical context of PHPT. Conclusion: The radiologic and histopathologic findings closely resemble each other in these cases. The biochemical diagnosis of PHPT is indispensable for an adequate differential diagnosis and treatment. (AACE Clinical Case Rep. 2018;4:e203-e208

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“…The most systemic bone disease with involvement of jaws was CGCG. This condition is an intraosseous lesion that rarely occurs in the Head and Neck region [38], involves the mandible more than the maxilla and is more common in second and third decade of life [39].…”

Section: Discussionmentioning

confidence: 99%

Radiological and Clinical Evaluation of Maxillofacial Cysts and Tumors in Patients Referred to Hospitals in Kermanshah during 2008 - 2012

Nikkerdar¹,

Azizi²,

Golshah³

2017

ME-JFM

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Background: Maxillofacial cysts and tumors are major causes of jawbone destruction; and may occasionally result in early mortality of patients. This study purposed to radiologically and clinically evaluate maxillofacial cysts and tumors among Iranian patients. Methods: A retrospective study was conducted on medical records of patients referred to surgical departments of two hospitals (Bisotun and Imam Khomeini) in Kermanshah, Iran, from 2008 to 2012. Totally, 347 records were reviewed and 85 cases with intraosseously maxillofacial lesions were selected. The information including age, gender, type of lesion and its characteristics (number of lesions, anatomic location, radiolucency, and lesion border) were collected. Data were presented by descriptive statistics using SPSS 20 software. Results: Overall occurrence of maxillofacial lesions was 24.5% (85/347) including 41 cysts, 14 benign tumors, 10 malignant tumors, and 20 bone diseases in jaws. The most common cysts, benign tumor, malignant tumor, and jawbone disease was radicular cyst (41.5%), ameloblastoma (57.1%), squamous cell carcinoma (75%), and central giant cell granuloma (65%), respectively. The posterior region of mandible and anterior part of maxilla were respectively identified as the first and second most common anatomic locations for development of the maxillofacial lesions. The peak age of patients was third and fourth decade for the majority of lesions but seventh and eighth decade for squamous cell carcinoma. Conclusions: Our findings are generally consistent with those reported in the literature. However, there are a few dissimilarities that may be due to racial and/or environmental differences.

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A central giant cell granuloma in posterior part of maxilla—A case report

Abstract: HighlightsRarity of the site of occurance.Innocuous clinical presentation.Conservative surgical approach.Long follow up period with no recurrence.

Cited by 21 publications

References 8 publications

Radiological features of Central Giant Cell Granuloma: Comparative study of 7 case reports and literature review

Radiological features of Central Giant Cell Granuloma: Comparative study of 7 case reports and literature review

Mandibular Brown Tumor as Atypical Presentation of Primary Hyperparathyroidism: two Case Reports And Literature Review

Radiological and Clinical Evaluation of Maxillofacial Cysts and Tumors in Patients Referred to Hospitals in Kermanshah during 2008 - 2012

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