A Central Role for IL-9 in Mediating Mast Cell Progenitor Mobilization to the Lung and Chronic Remodeling of the Airways.

Kearley, Jennifer; Erjefält, Jonas; Andersson, Cecilia; Burwell, TJ; Jones, T.; Benjamin, Emelia J.; Brewah, YA; Robinchaud, Amanda L; Pégorier, Sophie; Kölbeck, Karl‐Gustav; Kiener, PA; Gurish, M.F.; Lloyd, Clare M.; Coyle, AJ; Humbles, AA

doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3707

B101. Granulocyte Activation and Execution of Effector Functions in the Lung 2009

DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3707

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A Central Role for IL-9 in Mediating Mast Cell Progenitor Mobilization to the Lung and Chronic Remodeling of the Airways.

Jennifer Kearley

Jonas Erjefält

Cecilia Andersson

et al.

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2011

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“…Taken together, our results identify a unique role for IL-9 in the regulation of MC numbers in vivo and airway remodeling, and suggest an important link between IL-9, MCs, and fibrosis of the airways. Some of the results of these studies have been previously reported in the form of an abstract (16, 17).…”

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confidence: 92%

IL-9 Governs Allergen-induced Mast Cell Numbers in the Lung and Chronic Remodeling of the Airways

Kearley¹,

Erjefält²,

Andersson³

et al. 2011

Am J Respir Crit Care Med

189

165

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Rationale-IL-9 is a pleiotropic cytokine that has multiple effects on structural as well as numerous hematopoietic cells, which are central to the pathogenesis of asthma.Objectives-The contribution of IL-9 to asthma pathogenesis has thus far been unclear, due to conflicting reports in the literature. These earlier studies focused on the role of IL-9 in acute inflammatory models; here we have investigated the effects of IL-9 blockade during chronic allergic inflammation.Methods-Mice were exposed to either prolonged ovalbumin or house dust mite allergen challenge to induce chronic inflammation and airway remodeling.

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mentioning

confidence: 92%

IL-9 Governs Allergen-induced Mast Cell Numbers in the Lung and Chronic Remodeling of the Airways

Kearley¹,

Erjefält²,

Andersson³

et al. 2011

Am J Respir Crit Care Med

189

165

View full text Add to dashboard Cite

show abstract

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A Central Role for IL-9 in Mediating Mast Cell Progenitor Mobilization to the Lung and Chronic Remodeling of the Airways.

Cited by 1 publication

References 0 publications

IL-9 Governs Allergen-induced Mast Cell Numbers in the Lung and Chronic Remodeling of the Airways

IL-9 Governs Allergen-induced Mast Cell Numbers in the Lung and Chronic Remodeling of the Airways

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