A Century of Laffer-Ascher Syndrome

Abstract

Laffer-Ascher syndrome is characterized by double lips, blepharochalasis, and nongoiter thyroid enlargement. The syndrome was first described in 1923 and several case reports have been published thereafter. We illustrate the syndrome through a case of a 46-year-old woman who presented with both upper and lower double lips and blepharochalasis, and review the literature published.Thyroid involvement is the most inconsistent feature of the syndrome complex described in reported cases.