A century of research: what have we learned about the interaction of Trypanosoma cruzi with host cells?

Alves, Maria Júlia M.; Mortara, Renato Arruda

doi:10.1590/s0074-02762009000900013

Cited by 20 publications

(17 citation statements)

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“…Host cell invasion by T. cruzi trypomastigotes remains a highly a complex phenomenon that is likely initiated by the binding of several ligands to their receptors (Schofield et al 2006, Alves & Mortara 2009, followed by the triggering of the repair pathway, which involves injury and rapid membrane internalisation by the endocytic machinery (Fernandes et al 2011). Once inside the cell, trypomastigotes that are covered by the parasitophorous membrane actively move in the cytoplasm, providing the driving force that generates the protrusions that were described previously (Fernandes et al 2011) and further characterised in this paper.…”

Section: Discussionmentioning

confidence: 99%

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Trypanosoma cruzi trypomastigotes induce cytoskeleton modifications during HeLa cell invasion

Fernandes

Andrade

Andrews

et al. 2011

Mem. Inst. Oswaldo Cruz

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Section: Discussionmentioning

confidence: 99%

“…This process occurs in the acute phase of the disease or during reactivation following immunosuppression (Schofield et al 2006, Alves & Mortara 2009. T. cruzi triggers several host cell receptors and signalling pathways to invade cells (Burleigh & Woolsey 2002, Yoshida & Cortez 2008.…”

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confidence: 99%

Trypanosoma cruzi trypomastigotes induce cytoskeleton modifications during HeLa cell invasion

Fernandes

Andrade

Andrews

et al. 2011

Mem. Inst. Oswaldo Cruz

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“…Moreover, infection of cells by extracellular amastigotes is being characterized in recent years (Alves and Mortara 2009 ).…”

Section: Introduction: General Considerations On the Variability Of Tmentioning

confidence: 99%

The Gp85 Surface Glycoproteins from Trypanosoma cruzi

Mattos

Tonelli

Colli

et al. 2013

Subcellular Biochemistry

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Trypanosoma cruzi strains show distinctive characteristics as genetic polymorphism and infectivity. Large repertoires of molecules, such as the Gp85 glycoproteins, members of the Gp85/Trans-sialidase superfamily, as well as multiple signaling pathways, are associated with invasion of mammalian cells by the parasite. Due to the large number of expressed members, encoded by more than 700 genes, the research focused on this superfamily conserved sequences is discussed. Binding sites to laminin have been identified at the N-terminus of the Gp85 molecules. Interestingly, the T. cruzi protein phosphorylation profile is changed upon parasite binding to laminin (or fibronectin), particularly the cytoskeletal proteins such as those from the paraflagellar rod and the tubulins, which are both markedly dephosphorylated. Detailed analysis of the signaling cascades triggered upon T. cruzi binding to extracellular matrix (ECM) proteins revealed the involvement of the MAPK/ERK pathway in this event. At the C-terminus, the conserved FLY sequence is a cytokeratin-binding domain and is involved in augmented host cell invasion in vitro and high levels of parasitemia in vivo. FLY, which is associated to tissue tropism and preferentially binds to the heart vasculature may somehow be correlated with the severe cardiac form, an important clinical manifestation of chronic Chagas' disease.

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“…13,14 Vale destacar, também, as possibilidades que o conhecimento do genoma de T. cruzi representa na identificação de novos alvos. 15 Enzimas chave estão também entre os alvos preferidos para o desenvolvimento de novos fármacos. 16 …”

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Drug Design for Chagas'Disease: Advances and Challenges

Ferreira¹

2012

Revista Virtual De Química

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Abstract:The paper reports the general aspects about drug design and development, especially in the area of neglected diseases. The urre t s e ario is e phasized, the re e t ad a es i the Chagas' disease he otherapy are sho a d the main challenges to be faced are discussed as well as the perspectives of the contribution of the Brazilian Medicinal Chemistry and of the Laboratory of Design and Synthesis of Chemotherapeutic Agents potentially active on Neglected Diseases (LAPEN).Keywords: Drug Desig ; Drug De elop e t: Negle ted Diseases; Chagas' Disease; a ti-Chagas' disease he otherapy;Medicinal Chemistry; Brazilian Medicinal Chemistry; LAPEN. ResumoO artigo trata dos aspectos gerais do planejamento e desenvolvimento de fármacos, especialmente na área de doenças negligenciadas. Enfatiza o cenário atual, mostra os avanços recentes efetuados na quimioterapia da doença de Chagas e discute os principais desafios a serem enfrentados bem como a contribuição

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A century of research: what have we learned about the interaction of Trypanosoma cruzi with host cells?

Cited by 20 publications

References 231 publications

Trypanosoma cruzi trypomastigotes induce cytoskeleton modifications during HeLa cell invasion

Trypanosoma cruzi trypomastigotes induce cytoskeleton modifications during HeLa cell invasion

The Gp85 Surface Glycoproteins from Trypanosoma cruzi

Drug Design for Chagas'Disease: Advances and Challenges

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