A ceria NPs decorated graphene nano-composite sensor for sulfadiazine determination in pharmaceutical formulation

Ebrahimi, Mostafa; Nikoofard, Hossein; Faridbod, Farnoush; Dezfuli, Amin Shiralizadeh; Beigizadeh, Hana; Norouzi, Parviz

doi:10.1007/s10854-017-7583-1

Cited by 17 publications

(6 citation statements)

References 53 publications

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“…On the other hand, among the different electrodes used in electrochemical techniques, carbon paste electrodes (CPEs) have found a particular place due to their considerable advantages, including renewability, stable response, and low ohm resistance . Furthermore, to enhance the sensitivity of electrochemical sensors, novel nanomaterials, such as graphene and graphene oxide, have been widely applied in their structure.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous extraction and determination of trace amounts of diclofenac from whole blood using supported liquid membrane microextraction and fast Fourier transform voltammetry

Mofidi

Norouzi

Sajadian

et al. 2018

J of Separation Science

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A novel, simple, and inexpensive analytical technique based on flat sheet supported liquid membrane microextraction coupled with fast Fourier transform stripping cyclic voltammetry on a reduced graphene oxide carbon paste electrode was used for the extraction and online determination of diclofenac in whole blood. First, diclofenac was extracted from blood samples using a polytetrafluoroethylene membrane impregnated with 1-octanol and then into an acceptor solution, subsequently it was oxidized on a carbon paste electrode modified with reduced graphene oxide nanosheets. The optimal values of the key parameters influencing the method were as follows: scan rate, 6 V/s; stripping potential, 200 mV; stripping time, 5 s; pH of the sample solution, 5; pH of the acceptor solution,7; and extraction time, 240 min. The calibration curves were plotted for the whole blood samples and the method was found to have a good linearity within the range of 1-25 μg/mL with a determination coefficient of 0.99. The limits of detection and quantification were 0.1 and 1.0 μg/mL, respectively. Using this coupled method, the extraction and determination were merged into one step. Accordingly, the speed of detection for sensitive determination of diclofenac in complex samples, such as blood, increased considerably.

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Section: Introductionmentioning

confidence: 99%

Simultaneous extraction and determination of trace amounts of diclofenac from whole blood using supported liquid membrane microextraction and fast Fourier transform voltammetry

Mofidi

Norouzi

Sajadian

et al. 2018

J of Separation Science

Self Cite

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“…A well-defined peak was observed at 0.79 V vs. Ag/AgCl ( Figure 5 ) for sulfadiazine oxidation and at 0.78 V vs. Ag/AgCl ( Figure 6 ) for sulfamethazine oxidation. The sulfonamide functionality typically reports an oxidation peak assigned to the oxidation of the para position –NH 2 group ( Voorhies and Adams, 1958 ), at potentials ranging from 0.70 to 1.02 V vs. Ag/AgCl ( Fotouhi and Zabeti, 2014 ; Ebrahimi et al, 2017 ; Su and Cheng, 2018 ). The sulfonamides evaluated in this work showed oxidation peaks between 0.75 and 0.78 V vs. Ag/AgCl, depending on the specific sulfonamide drug investigated.…”

Section: Resultsmentioning

confidence: 99%

“…A comparison of the sensitivity of carbon-based nanomaterial electrodes toward sulfonamide detection showed that carbon nanotubes and PAA electrospun nanofibers outperformed nanoparticles, molecularly imprinted methods, and polymer blends used in the preparation of transducers for the detection of sulfonamides using the SWV method ( Sadeghi and Motaharian, 2013 ; Fotouhi and Zabeti, 2014 ; Ebrahimi et al, 2017 ; Su and Cheng, 2018 ; Urzúa et al, 2018 ). The implication of the structure and size as opposed to size only, in efficiency of catalysis, is therefore substantiated.…”

Section: Resultsmentioning

confidence: 99%

Spectroscopy, Morphology, and Electrochemistry of Electrospun Polyamic Acid Nanofibers

et al. 2022

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Polyamic acid (PAA) nanofibers produced by using the electrospinning method were fully characterized in terms of morphology and spectroscopy. A PAA nanofiber–modified screen-printed carbon electrode was applied to the detection of selected sulfonamides by following an electroanalytical protocol. The polyamic acid (PAA) nanofibers were characterized using Fourier transform infrared (FTIR) spectroscopy to study the integrity of polyamic acid functional groups as nanofibers by comparing them to chemically synthesized polyamic acid. A scanning electron microscope (SEM) was used to confirm the morphology of the produced nanofibers and 3D arrangement at the electrode interface. The Brunauer–Emmett–Teller (BET) method was used to determine the surface area of the nanofibers. Atomic force microscopy (AFM) was used to study the porosity and surface roughness of the nanofibers. Electrochemical evaluation based on diffusion-controlled kinetics was applied to determine the number of electrons transferred in the system, the surface concentration of the deposited PAA thin film (2.14 × 10−6 mol/cm2), and the diffusion coefficient (De) for the PAA nanofiber–modified screen-printed carbon electrode (9.43 × 10−7 cm−2/s). The reported LODs for sulfadiazine and sulfamethazine detection are consistent with requirements for trace-level monitoring by early warning diagnostic systems.

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“…No que diz respeito às aplicações, muitas estão focadas no monitoramento de antibióticos em amostras de interesse clínico, farmacêutico e alimentício (CESARINO et al, 2016;DA SILVA et al, 2018;EBRAHIMI et al, 2017;GOVINDASAMY et al, 2019;HUANG et al, 2017;KUMAR et al, 2017;MATERÓN et al, 2021;YUE et al, 2020).…”

Section: Eletrodos Modificados Com Grafenounclassified

“…Ebrahimi e colaboradores desenvolveram um eletrodo de pasta de carbono (CPE, do inglês Carbon Paste Electrode) contendo 5% m/m de nanocompósito de rGO e óxido de cério para a quantificação de sulfadiazina em amostras de formulações farmacêuticas por SWV. Resultados concordantes com os valores fornecidos pelos rótulos dos medicamentos foram verificados (EBRAHIMI et al, 2017).…”

Section: Eletrodos Modificados Com Grafenounclassified

Desenvolvimento de métodos eletroanalíticos utilizando sensor a base de grafeno para a determinação de antibióticos em amostras de leite e formulações farmacêuticas

Faria¹

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Os antibióticos correspondem à maior e mais importante classe de fármacos utilizada pela medicina humana e veterinária, em virtude de apresentarem propriedades antibacterianas para o tratamento de diversas enfermidades. O uso de nanomateriais a base de carbono, principalmente o grafeno, vem desempenhando um importante papel para construção de novos sensores eletroquímicos. Dessa forma, o principal objetivo deste trabalho foi desenvolver métodos eletroanalíticos simples, rápidos, sensíveis e de baixo custo, usando o eletrodo de carbono vítreo modificado com óxido de grafeno reduzido (GCE/rGO) para a avaliação de ciprofloxacina (CIP), tetraciclina (TET) e cloranfenicol (CLO) em formulações farmacêuticas e leite. Estudos usando a voltametria cíclica na presença de cada um dos antibióticos mostraram um efeito eletrocatalítico do rGO sobre os diferentes processos eletroquímicos, tendo em vista os consideráveis incrementos de corrente e antecipação dos potenciais frente ao eletrodo não modificado. O desempenho analítico do GCE/rGO para a quantificação dos antibióticos foi investigado usando a voltametria de onda quadrada e voltametria de pulso diferencial, e em sistemas de análise em fluxo e batelada com detecção amperométrica. Todos os métodos propostos apresentaram desvio padrão relativo inferiores a 7,0 %, demonstrando uma adequada precisão. Os valores de limites de detecção (LD) obtidos foram menores que 1,0 µmol L-1 para CIP, TET e CLO. Para as aplicações dos métodos nas amostras farmacêuticas e de leite, estas foram simplesmente diluídas (50 vezes) em eletrólito suporte tampão Britton-Robinson (0,04 mol L-1 ). Percentuais de recuperação na faixa de 84 a 117 % atestaram ausência do efeito de matriz da amostra. Os níveis dos antibióticos nas amostras de leite ficaram abaixo dos valores de LD, enquanto que nas formulações farmacêuticas, os teores dos princípios ativos foram concordantes com os valores fornecidos pelos fabricantes. Todos os resultados obtidos eletroquimicamente foram devidamente comparados às análises cromatográficas, não havendo indícios de diferenças significativas, à 95 % de confiabilidade, o que indicou uma boa exatidão dos métodos. Dessa forma, os métodos desenvolvidos são confiáveis e promissoras para implementação no controle de qualidade de medicamentos e no monitoramento de resíduos de antibióticos em leite.

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A ceria NPs decorated graphene nano-composite sensor for sulfadiazine determination in pharmaceutical formulation

Cited by 17 publications

References 53 publications

Simultaneous extraction and determination of trace amounts of diclofenac from whole blood using supported liquid membrane microextraction and fast Fourier transform voltammetry

Simultaneous extraction and determination of trace amounts of diclofenac from whole blood using supported liquid membrane microextraction and fast Fourier transform voltammetry

Spectroscopy, Morphology, and Electrochemistry of Electrospun Polyamic Acid Nanofibers

Desenvolvimento de métodos eletroanalíticos utilizando sensor a base de grafeno para a determinação de antibióticos em amostras de leite e formulações farmacêuticas

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