A cerium-based metal–organic framework having inherent oxidase-like activity applicable for colorimetric sensing of biothiols and aerobic oxidation of thiols

Dalapati, Rana; Sakthivel, B.; Ghosalya, Manoj Kumar; Dhakshinamoorthy, Amarajothi; Biswas, Shyam

doi:10.1039/c7ce01053b

Cited by 113 publications

(58 citation statements)

References 71 publications

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“…The studies by Cao et al (2017) revealed that ruthenium nanoparticles (Ru) exhibit their own oxidase activity, catalyzing the oxidation of tetramethylbenzidine (TMB) and sodium L-ascorbate with dissolved oxygen. Similar activity was demonstrated by Pt nanoparticles (Deng et al, 2017), Au (He et al, 2011), Ir (Cui et al, 2017), CoFe 2 O 4 (Zhang et al, 2013), ZnFe 2 O 4 (Su et al, 2012), MnO 2 (Yan et al, 2017), CeO 2 (Dalapati, 2017;Estevez et al, 2017), NiCo 2 O 4 (Song et al, 2018), Se (Guo et al, 2016) and other metals and composites. It was determined that the maximum mimetic activity depends on particular physical parameters.…”

Section: Nanomaterials As Oxidase Mimeticssupporting

confidence: 61%

Enzyme-like activity of nanomaterials

Tsekhmistrenko

Bityutskyy

Цехмістренко

et al. 2018

Regul. Mech. Biosyst.

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In modern conditions, nanomaterials, especially nanoparticles of metals and nonmetals, are increasingly used in various industries. Due to their unique properties, in particular, the ability of nanoparticles to exhibit an enzyme-like effect they are widely used in biology, medicine, biotechnology, the food industry and agriculture. Important advantages of nanoparticles are their size, which enables specific properties to be present: their large surface area, the ability to transfer molecules and the ability to protect them from degradation and release over a long time, the location of action and the specificity of interaction with biological structures. Nanoparticles play a special role in the processes of neutralizing the active forms of oxygen. It has been established that a number of nanoparticles, in particular, Fe, Mn, Zn, Ce, Si and Se oxides, have an enzyme-like activity mimicking that of some enzymes. By changing the degree of oxidation, these particles can regenerate and continuously catalyze the reaction of neutralizing superoxide anion radicals, thus fulfilling the function of SOD and being the first link in protecting tissues and cells from oxidative stress in physiological and pathological conditions. It is proved that nanoparticles Mn3O4, Fe3O4, Co3O4, CeO2, LaCoO3 and other elements can effectively dispose of hydrogen peroxide and other peroxides, showing catalase-like and peroxidase-like activity. Nanozymes are characterized that exhibit the activity of oxidases, peroxidases and phosphatase. The prospect of using mimetics for complex in vitro analyzes of high-sensitivity biomarker disease detection is shown. The possibility of effective multi-use of nanoparticles as antioxidants is indicated. There are good prospects for further research on properties and the use of polyfunctional particles that are easily synthesized, reliable and inexpensive. More work is needed to determine the interaction of enzymomimetics with biological molecules such as proteins, carbohydrates and lipids, and also to take into account the peculiarities of their metabolism, clearance, degradation, biocompatibility and side effects, since individual nanoparticles have the potential to be deposited in separate organs.

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Section: Nanomaterials As Oxidase Mimeticssupporting

confidence: 61%

Enzyme-like activity of nanomaterials

Tsekhmistrenko

Bityutskyy

Цехмістренко

et al. 2018

Regul. Mech. Biosyst.

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“…Comparison of the kinetic constants of FeN5 SA/CNF and nanozymes. References (44)(45)(46)(47)(48)(49)(50)(51)…”

Section: Supplementary Materialsmentioning

confidence: 99%

Single-atom nanozymes

et al. 2019

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Conventional nanozyme technologies face formidable challenges of intricate size-, composition-, and facet-dependent catalysis and inherently low active site density. We discovered a new class of single-atom nanozymes with atomically dispersed enzyme-like active sites in nanomaterials, which significantly enhanced catalytic performance, and uncovered the underlying mechanism. With oxidase catalysis as a model reaction, experimental studies and theoretical calculations revealed that single-atom nanozymes with carbon nanoframe–confined FeN5 active centers (FeN5 SA/CNF) catalytically behaved like the axial ligand–coordinated heme of cytochrome P450. The definite active moieties and crucial synergistic effects endow FeN5 SA/CNF with a clear electron push-effect mechanism, as well as the highest oxidase-like activity among other nanozymes (the rate constant is 70 times higher than that of commercial Pt/C) and versatile antibacterial applications. These suggest that the single-atom nanozymes have great potential to become the next-generation nanozymes.

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“…Other examples in the literature reporting the use of UiO-66 type materials as catalysts for the oxidation of benzyl alcohol, [42] thiophenol, [43] cyclohexene [44] and Ti IV supported as part of the node in UiO-66 for the oxidation of cyclohexene using hydrogen peroxide [45] have also been reported.…”

Section: Nodes As Redox Sitesmentioning

confidence: 99%

Engineering UiO‐66 Metal Organic Framework for Heterogeneous Catalysis

et al. 2019

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frameworks (MOFs) are currently attracting considerable attention as heterogeneous catalysts at moderate temperatures, mainly for liquid-phase reactions. Since structural stability is one of the major concerns for the use of MOFs in catalysis, particularly considering that frequently some of the reported MOF materials are very unstable, the interest in this area has been focused on those MOFs exhibiting the highest structural robustness, UiO-66 being among the most widely used. Two introductory sections deal with the synthesis, structure and main properties of UiO-66, including its remarkable thermal (up to 350°C) and chemical (aqueous solution in a wide pH range) stability. The main body of the review summarizes those examples of using UiO-66 in catalysis grouped according to the nature of the active sites, starting with the use of UiO-66 as Lewis acids. In this section, emphasis has been made in the recent strategies to create structural defects in a controlled way that generate Lewis acidity. Other sections cover examples illustrating substituted terephthalate as active sites and the evidence that there is a synergy between acid and basic sites in close proximity that make some of these UiO-66 with substituents at the linker to act as dual acid-base catalysts. Other sections are focused on the use of UiO-66 as hosts of metal nanoparticles, metal oxides and other host, remarking the influence that the nature of UiO-66 and the possible presence of substituents in the framework play on the activity of the incorporated guest. The last section summarizes the current state of the art in the use of UiO-66 in catalysis and provides our views on future developments regarding the application of UiO-66 in industrial processes.

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A cerium-based metal–organic framework having inherent oxidase-like activity applicable for colorimetric sensing of biothiols and aerobic oxidation of thiols

Abstract: A cerium-based MOF exhibits oxidase-like activity for colorimetric sensing of biothiols and aerobic oxidation of thiols.

Cited by 113 publications

References 71 publications

Enzyme-like activity of nanomaterials

Enzyme-like activity of nanomaterials

Single-atom nanozymes

Engineering UiO‐66 Metal Organic Framework for Heterogeneous Catalysis

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