A cerium oxide-based nanomedicine for pH-triggered chemodynamic/chemo combination therapy

Abstract

Chemodynamic therapy (CDT) is a kind of novel cancer treatment with minimized side effects. As the therapeutic efficacy of a single CDT is usually not satisfactory, combining other therapeutic modalities...

Tumor‐Microenvironment‐Responsive Cerium‐Enriched Copper Nanozyme with O2 Supply and Oxidative Stress Amplification for In Situ Disulfiram Chemotherapy and Chemodynamic Therapy Intensification

“…[32][33][34][35][36][37][38] Chemodynamic therapy has emerged as an effective anticancer modality by catalyzing the production of highly toxic reactive oxygen species (ROS) through the conversion of endogenous H 2 O 2 using Fenton chemistry. [39][40][41][42][43] Notably, as in situ treatment, chemodynamic therapy is substantially activated under a tumor microenvironment with sufficient H 2 O 2 and acidity, resulting in high selection and specificity to tumors while reducing side effects to normal tissues. [44,45] Considering the synergistic therapy with Cu/DSF-based chemotherapy, the selection of appropriate nanomaterials for chemodynamic therapy is crucial to the ultimate antitumor effect.…”

Osteosarcoma-targeted Cu and Ce based oxide nanoplatform for NIR II fluorescence/magnetic resonance dual-mode imaging and ros cascade amplification along with immunotherapy

“…In particular, Cu-based nanomedicine with exceptional biocompatibility has played an increasingly significant role in multifunctional nanoplatform for tumor diagnosis, for instance, it can act as an effective contrast agent with amplified signal for magnetic resonance imaging (MRI) [28,29]. As various CDT nanoagents have been earnestly explored, among the lanthanide elements, cerium based nanotherapeutics have received widespread concern on account of their exceeding redox feature and capability to realize reversible transformation between Ce 4+ and Ce 3+ for converting H 2 O 2 to •OH [30][31][32][33]. In concordance with Cu 2+ , Ce 4+ has also contributed to accelerate GSH consumption through redox reaction, therefore attenuating its •OH scavenging efficiency.…”

Water-soluble ferrous metallacage combined with oxaliplatin for a synergistic chemo/chemodynamic therapy

“…Chemodynamic therapy (CDT) catalyses the Fenton or Fentonlike reaction of hydrogen peroxide (H 2 O 2 ) to produce the highly cytotoxic hydroxyl radical ( OH) to kill tumors. [1][2][3][4] Due to its advantages of high specificity, low side effects and negligible drug resistance, CDT has attracted much attention for tumor treatment. However, there are still some problems hindering the application of CDT, such as the Fenton reaction activity, H 2 O 2 content and short lifetime of OH.…”