A challenge to establish in vitro anti-thrombogenic test methodology for artificial organs using a novel air-contactless pulsatile simulator

Iwasaki, Katsurô; Saeki, Wataru; Takeuchi, Yuuri; Umezu, Mitsuo; Ishihara, Kazuhíko; Imachi, Kou; Sakurai, Yasuhisa

doi:10.1299/jsmebio.2004.16.217

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Blood compatibility under flow conditions using a blood pump and circuit. Images on the left show the complete experiment set up, and those on the right are SEM images of the surface after 1 h of blood circulation …”

Section: Biological Reactions At the Polymer Surfacementioning

confidence: 99%

“…In one study, whole blood responses under flow conditions are observed using a diaphragm-type blood pump made by segmented polyurethane (SPU) (Figure 4). 83 The PMB30 can be coated on the SPU easily by a solution-casting procedure. 84 The inner surface of the pump is coated with PMB30, and whole blood is circulated through the blood circuit.…”

Section: ■ Biologically Inert Surfaces Prepared By Polymers With Pc G...mentioning

confidence: 99%

See 1 more Smart Citation

Blood-Compatible Surfaces with Phosphorylcholine-Based Polymers for Cardiovascular Medical Devices

2018

Self Cite

View full text Add to dashboard Cite

For the acquisition of blood-compatible materials, various hydrophilic polymers for surface modification have been examined. Among them, polymers with a representative phospholipid polar group, the phosphorylcholine (PC) group, are a successful example. These polymers were designed from inspiration of the cell membrane surface and provide protein adsorption resistance even following contact with plasma. This important property is based on the unique hydration state of water molecules surrounding hydrated polymer; in other words, water molecules weakly interact with the polymers and maintain their favorable cluster structure through hydrogen bonding. These polymers are not only hydrophilic, but also electrically neutral, important characteristics which make hydrogen bonding with water molecules less likely to occur and avoid hydrophobic interactions. Phosphorylcholine groups and other zwitterionic structures are significant as hydrophilic functional groups meeting these important requirements. In this review, blood compatibility of a polymer having a PC group is introduced in relation to its hydration structure, followed by a description of the applications of this polymer to cardiovascular medical devices.

show abstract

Section: Biological Reactions At the Polymer Surfacementioning

confidence: 99%

Section: ■ Biologically Inert Surfaces Prepared By Polymers With Pc G...mentioning

confidence: 99%

Blood-Compatible Surfaces with Phosphorylcholine-Based Polymers for Cardiovascular Medical Devices

2018

Self Cite

View full text Add to dashboard Cite

show abstract

A challenge to establish in vitro anti-thrombogenic test methodology for artificial organs using a novel air-contactless pulsatile simulator

Cited by 1 publication

References 0 publications

Blood-Compatible Surfaces with Phosphorylcholine-Based Polymers for Cardiovascular Medical Devices

Blood-Compatible Surfaces with Phosphorylcholine-Based Polymers for Cardiovascular Medical Devices

Contact Info

Product

Resources

About