A challenging case of ALK-negative anaplastic large cell lymphoma in a 12-year-old boy: A rare case report from Syria

A Case of Anaplastic Large Cell Lymphoma Misdiagnosed with Keloid

“…Anaplastic large cell lymphoma (ALCL) is a rare and aggressive form of non-Hodgkin’s lymphoma (NHL) that accounts for approximately 2% of all lymphoma tumours, 1 it occurs more frequently in adult males and often presents as limited purple papules, nodules, and plaques, often indicating shallow ulcers, either solitary or multiple. Depending on the site of origin, these lesions can be classified as systemic ALCL, primary cutaneous ALCL (pC-ALCL) and breast implant-associated ALCL (BIA-ALCL).…”

“…Anaplastic large cell lymphoma (ALCL)is a subtype of peripheral T-cell lymphoma, first reported by Stein et al in 1985, and is usually seen in children and young adults, accounting for 10–15% of paediatric NHL and only 2% of adult NHL. 1 Primary cutaneous anaplastic large cell lymphoma (pC-ALCL) is a subtype of anaplastic large cell lymphoma. pC-ALCL is a CD30-positive proliferative disease of cutaneous lymphoid tissue with large tumour cells that have a pleomorphic, mesenchymal or immunoblast cell pattern.…”