A challenging case of multiple splenic and pancreatic lesions in a patient with Crohn's disease

Boschetti, Gilles; Assaad, Souad; Balme, B.; Boyer, Sylvie; Flourié, Bernard; Nancey, Stéphane

doi:10.1136/gutjnl-2015-310130

Cited by 5 publications

(3 citation statements)

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“…A total of 37 cases of IBD-associated AA were found in our literature search of MEDLINE, EMBASE, and CINAHL and through hand-searching. These articles were published from 1994 [ 6 ] to 2016 [ 20 , 21 ]. The clinical characteristics of these cases can be found in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…With regard to types of IBD, both of our patients had UC compared to only 24.3% ( n = 9) of patients reported in the literature. A recent case report by Boschetti et al of AA described a diagnosis of multiple systemic abscess syndrome, though they called this a complication of CD and not IBD, removing patients with UC from consideration [ 21 ]. Despite the higher incidence of CD, compared to UC-associated AA, it is important for clinicians to realize that AA can be an EIM regardless of the type of underlying IBD.…”

Section: Discussionmentioning

confidence: 99%

“…Maintenance therapy should follow because relapse is common, as seen in over half of the patients in the literature review and in one of our two patients. Interestingly, no patients in the literature experienced relapse while on maintenance therapy of azathioprine, sulfasalazine, adalimumab, or infliximab, although the durability of this response is unknown [ 7 , 8 , 10 , 13 , 17 , 19 , 21 ]. There were no reported fatal outcomes.…”

Section: Discussionmentioning

confidence: 99%

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Aseptic Abscesses and Inflammatory Bowel Disease: Two Cases and Review of Literature

Bollegala

Khan

Scaffidi

et al. 2017

Canadian Journal of Gastroenterology and Hepatology

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Background. Aseptic abscesses (AA) are sterile lesions that represent an extraintestinal manifestation (EIM) of inflammatory bowel disease (IBD). Though Canada has the highest prevalence of IBD in the world, reports of IBD-associated AA are absent in Canada. This may represent a different IBD phenotype or underrecognition and underreporting. Purpose. To explore AA as a possible EIM of IBD and evaluate clinical and investigative findings among patients with IBD-associated AA. Methods. Retrospective chart and literature reviews were performed to find cases of IBD-associated AA at our institution and in the literature. Results. We identified 2 cases of IBD-associated AA in our institution. Both patients had ulcerative colitis and presented with fever, abdominal pain, and weight loss. Radiological workup and aspiration showed sterile splenic abscesses. The AA were unresponsive to antibiotics. One patient improved on corticosteroids and one underwent splenectomy. We retrieved 37 cases of IBD-associated AA from the literature. All patients showed no evidence of infection, failed to resolve with antibiotics, and, if attempted, improved on corticosteroids. Conclusions. Our cases are the first reported in Canada. They support literature which suggests AA as an EIM of IBD and may help increase recognition and reporting of this phenomenon.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%