A Challenging Synthesis of New 1,3,4‐Thiadiazole Derivatives Starting from 2‐Acylamino‐3,3‐dichloroacrylonitriles.

Abstract

Thiadiazole derivatives R 0300A Challenging Synthesis of New 1,3,4-Thiadiazole Derivatives Starting from 2-Acylamino-3,3-dichloroacrylonitriles. -The addition of isocyanates (III) to 2-substituted 5-hydrazino-1,3-oxazole-4-carbonitriles (II) in refluxing dioxane results in the formation of thiadiazol-2-yl(acylamino)acetonitriles (V) or products of their further cyclization (VI) depending on the type of the 2-substituent in starting oxazole (II).-(GOLOVCHENKO, O. V.; PILYO, S. G.; BROVARETS, V. S.; CHERNEGA, A. N.; DRACH, B. S.; Heteroat. Chem. 15 (2004) 6, 454-458; Inst. Bioorg. Chem. Petrochem., Acad. Sci. Ukr., Kiev 253660, Ukraine; Eng.) -R. Staver 05-114