A change in inhibitory mechanism of Na+ deficiency on high K+-induced contraction in rat uterus with the progress of pregnancy.

Kamizaki, Junji; Shimizu, Kazumasa; Nakajyo, Shinjiro; Urakawa, Norimoto

doi:10.1540/jsmr1965.26.151

Cited by 2 publications

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“…Application of hyperosmotically-added high-K + solution induced a sustained contraction, while an isosmotically-substituted high-K + , Na + -deficient solution induces contraction followed by gradual relaxation in various smooth muscles [10,11,[17][18][19][21][22][23][24]. The possible mechanism of these changes in muscle contractility of tonic muscle is swelling of the cells, as in rabbit aorta [21] and guinea pig trachea [17].…”

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Effects of High-K+, Na+-Deficient Solution on Contractility of the Smooth Muscles of the Bovine Trachea

Kaneda

SAKAGUCHI

Shimizu

et al. 2006

The Journal of Veterinary Medical Science

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ABSTRACT. A high-K + , Na + -deficient (I-154 K + ) solution induced contraction followed by gradual relaxation of the smooth muscles of the bovine trachea, while hyperosmotic addition of 65 mM KCl induced a large sustained contraction. Exposure of the muscle to the I-154 K + solution induced an increase in the ratio of cellular water content and a sustained increase in oxidized flavoprotein fluorescence or reduced pyridine nucleotide fluorescence. The I-154 K + solution also induced a sustained increase in [Ca 2+ ]i level. Decreases in developed tension and increases in cellular water content were both prevented by the addition of sucrose or NaCl but not pyruvate. Substitution of KI for KCl in the I-154 K + solution produced a greater inhibition of contraction, while substitution with K-propionate produced no inhibition of contraction. Moreover, decreases in developed tension and increases in cellular water content were both prevented by addition of 100 µM 4,4'-diisothiocyanatostilbene-2,2'-disulphonic acid (DIDS), but not 10 µM bumetanide or 1 mM acetazolamide. In conclusion, I-154 K + solution induced-relaxation in the bovine trachea may be due to swelling of smooth muscle cells and the mechanism of swelling is probably involved in DIDS-sensitive anion movement.

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Effects of High-K+, Na+-Deficient Solution on Contractility of the Smooth Muscles of the Bovine Trachea

Kaneda

SAKAGUCHI

Shimizu

et al. 2006

The Journal of Veterinary Medical Science

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“…Moreover, the inhibition of glucose utilization in I-154 K + medium in porcine trachea is different from that of bovine trachea. Application of hyperosmotically-added high-K + solution induced a sustained contraction, while an isosmotically-substituted high-K + , Na + -deficient solution induces contraction followed by gradual relaxation in various smooth muscles [5][6][7][15][16][17][18][19][20][21]. The possible mechanism of these decreases in muscle contractility of tonic muscle is swelling of the cells, as in rabbit aorta [19].…”

Section: + -Deficient Solution On Contractility Of the Smooth Musclesmentioning

confidence: 99%

Effects of High-K+, Na+-Deficient Solution on Contractility of the Smooth Muscles of the Porcine Trachea

Kaneda

Kanakura

Yamamoto

et al. 2009

The Journal of Veterinary Medical Science

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ABSTRACT. A high-K + , Na + -deficient (isosmotic 154 mM K + and 0 mM Na + ; I-154 K + ) solution induced contraction followed by gradual relaxation of the smooth muscles of the porcine trachea, while hyperosmotic addition of 65 mM KCl (H-65 K + ) induced a large sustained contraction. The I-154 K + solution also induced a sustained increase in [Ca 2+ ] i level. Decreases in muscle tension and increases in cellular water content were both prevented by the addition of sucrose or NaCl in the porcine trachea. An additional application of phloridzin inhibited recoveries of I-154 K + solution by addition of NaCl in the porcine trachea. Addition of pyruvate or oxaloacetate recovered the I-154 K + solution-induced relaxation in the porcine trachea. Although application of I-154 K + solution did not affect PCr and ATP contents in the bovine trachea, the solution induced a gradual decrease of PCr content in the porcine trachea. Moreover, application of pyruvate or oxaloacetate recovered the I-154 K + solution-induced decreases of PCr content in the porcine trachea. Phloridzin inhibited H-65 K + -induced contraction in porcine, but not in bovine trachea. In conclusion, the I-154 K + solution-induced relaxation in the porcine trachea is probably due to swelling of cells and inhibition of glucose utilization. Moreover, the inhibition of glucose utilization in I-154 K + medium in porcine trachea is different from that of bovine trachea.

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A change in inhibitory mechanism of Na+ deficiency on high K+-induced contraction in rat uterus with the progress of pregnancy.

Abstract: On the other hand, iso-154K+solution remarkably increased the relative cellular water content in the early or middle stage muscle, but moderately in the late or end stage one. In

Cited by 2 publications

References 12 publications

Effects of High-K+, Na+-Deficient Solution on Contractility of the Smooth Muscles of the Bovine Trachea

Effects of High-K+, Na+-Deficient Solution on Contractility of the Smooth Muscles of the Bovine Trachea

Effects of High-K+, Na+-Deficient Solution on Contractility of the Smooth Muscles of the Porcine Trachea

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