A change in serum myoglobin to detect acute myocardial infarction in patients with normal troponin I levels

2011 ACCF/AHA Focused Update Incorporated Into the ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction

“…[252][253][254][255][256] Studies have reported that multimarker measurements at baseline and 90 min have a sensitivity for MI of approximately 95% with a high negative predictive value, thus allowing for the early exclusion of MI when combined with clinical judgment. 254,255 However, because of the low specificity of the multimarker strategy (mainly due to the lower specificity of myoglobin), a positive multimarker test is inadequate to diagnose MI and requires confirmation with a later-appearing definitive marker.…”

2012 ACCF/AHA Focused Update Incorporated Into the ACCF/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction

“…[258][259][260][261][262] Studies have reported that multimarker measurements at baseline and 90 min have a sensitivity for MI of approximately 95% with a high negative predictive value, thus allowing for the early exclusion of MI when combined with clinical judgment. 260,261 However, because of the low specificity of the multimarker strategy (mainly due to the lower specificity of myoglobin), a positive multimarker test is inadequate to diagnose MI and requires confirmation with a later-appearing definitive marker.…”

Directed immobilization of reduced antibody fragments onto a novel SAM on gold for myoglobin impedance immunosensing

“…The level of myoglobin significantly elevates as early as 1 h after the onset of AMI and peaks within 3-6 h [19][20][21][22][23]. The short halflife of myoglobin due to its relatively low Mr of 17.8 kDa allows it to clear from the blood within 24 h [24].…”