A change-prone zwitterionic hyperbranched terpolymer-based diabetic wound dressing

Xie, Xianhua; Jin, Xin; He, Binbin; Zhan, Yang; Yang, Jumin; Liu, Changjun; Kong, Xiaoling; Liu, Wenguang; Wang, Wei

doi:10.1016/j.apmt.2022.101477

Cited by 6 publications

(10 citation statements)

References 52 publications

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“…Bioactive glass has been extensively applied in tissue engineering, due to its capacity to stimulate angiogenesis and repair soft tissue wounds [ 125 ], while cerium displayed significant antibacterial properties against both Gram positive and Gram negative bacteria [ 126 ]. Alternatively, in situ UV-initiated hydrogel was synthetized by chemical crosslinking of GL-MA and zwitterionic hyperbranched terpolymer prepared by a dynamically controllable reversible addition-fragmentation chain transfer [ 127 ]. This carrier was successfully proposed to transport Ag + ions complexed with the anti-inflammatory ascorbyl palmitate nanosheets.…”

Section: Polymeric Compoundsmentioning

confidence: 99%

Natural Compounds and Biopolymers-Based Hydrogels Join Forces to Promote Wound Healing

et al. 2023

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Rapid and complete wound healing is a clinical emergency, mainly in pathological conditions such as Type 2 Diabetes mellitus. Many therapeutic tools are not resolutive, and the research for a more efficient remedial remains a challenge. Wound dressings play an essential role in diabetic wound healing. In particular, biocompatible hydrogels represent the most attractive wound dressings due to their ability to retain moisture as well as ability to act as a barrier against bacteria. In the last years, different functionalized hydrogels have been proposed as wound dressing materials, showing encouraging outcomes with great benefits in the healing of the diabetic wounds. Specifically, because of their excellent biocompatibility and biodegradability, natural bioactive compounds, as well as biomacromolecules such as polysaccharides and protein, are usually employed in the biomedical field. In this review, readers can find the main discoveries regarding the employment of naturally occurring compounds and biopolymers as wound healing promoters with antibacterial activity. The emerging approaches and engineered devices for effective wound care in diabetic patients are reported and deeply investigated.

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Section: Polymeric Compoundsmentioning

confidence: 99%

Natural Compounds and Biopolymers-Based Hydrogels Join Forces to Promote Wound Healing

et al. 2023

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“…The mechanical properties are crucial to the hydrogels in supporting the wound and accelerating its healing. [ 30 ] As shown in Figure 3G,H, GUF‐5 hydrogel exhibits the highest tensile strength (0.42 ± 0.07 MPa) and a Young's modulus of 0.28 ± 0.05 MPa which is lower than that of PDMS (0.77 ± 0.03 MPa) (Figure S4B, Supporting Information). This is a prerequisite for the microneedle of the PPDMS‐MNS to be inserted into the gel.…”

Section: Resultsmentioning

confidence: 99%

“…To verify the practical efficacy of GUFO oxydevice on wound healing, a full‐thickness excisional skin wound model on a diabetic rat was established ( Figure A) and a silicone ring was employed to hinder rapid shrinkage. [ 30 ] The wounds treated with phosphate buffer saline (PBS group), GU‐5 hydrogel (GU group), and GUF‐5 hydrogel (GUF group) were set as controls, and wounds treated by GUFO oxydevice (GUFO group) were supplied with 808 nm NIR irradiation with a power density of 0.99 W cm −2 at a distance of 1 cm for 5 min twice a day. The curves of body weight and blood glucose level of rats in each group at different time points revealed the successful establishment of the diabetic model (Figure S22, Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

A Programmable Oxygenation Device Facilitates Oxygen Generation and Replenishment to Promote Wound Healing

Yang,

Jin,

Liu

et al. 2023

Advanced Materials

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Inadequate oxygenation is one of the chief culprits for delayed wound healing. However, current oxygen therapies, such as hyperbaric oxygen therapy and topical oxygen therapy, face hurdles in providing sustained and long‐term oxygenation to reverse wound hypoxia. Furthermore, their efficacy in rejuvenating wound injury is restricted by limited penetration of oxygen in the wound bed. Herein, this study proposes a programmable and portable oxygenation device (named GUFO oxydevice) by ingeniously integrating (i) a controllable oxygen generation and unidirectional transmission system (COGT‐UTS), and (ii) a supramolecular assembled perfluorinated hyperbranched polymer/gelatin (GUF) hydrogel in which the perfluorinated hyperbranched polymer (FHBP) acts as an oxygen reservoir to ensure sustained and convenient oxygen replenishment and thus directly regulate the hypoxic wound microenvironment. Accelerating the wound healing process by GUFO oxydevice was achieved in both a diabetic rat and an acute porcine wound model without any secondary tissue damages. The present study demonstrates that the GUFO oxydevice holds promise as a practically feasible candidate for wound treatment.This article is protected by copyright. All rights reserved

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“…The zwitterionic hydrogel substrates can be used as a hydrogel dressing to resist external bacterial adhesion and absorb wound exudate to maintain a suitable moist environment conducive to better wound recovery. 21 The prepared HMPs were loaded into the microneedle substrates as photothermal converters to provide excellent photothermal properties to achieve more efficient bactericidal effects.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional zwitterionic microneedle dressings for accelerated healing of chronic infected wounds in diabetic rat models

Cai

et al. 2023

Biomater. Sci.

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A change-prone zwitterionic hyperbranched terpolymer-based diabetic wound dressing

Cited by 6 publications

References 52 publications

Natural Compounds and Biopolymers-Based Hydrogels Join Forces to Promote Wound Healing

Natural Compounds and Biopolymers-Based Hydrogels Join Forces to Promote Wound Healing

A Programmable Oxygenation Device Facilitates Oxygen Generation and Replenishment to Promote Wound Healing

Multifunctional zwitterionic microneedle dressings for accelerated healing of chronic infected wounds in diabetic rat models

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