A characterization of the antioxidant enzyme activity and reproductive toxicity in male rats following sub-chronic exposure to areca nut extracts

Wu, Po-Han; Chiang, Tai‐An; Chen, Min-Tzu; Lee, Chi‐Pin; Chen, Ping-Ho; Ko, Albert Min-Shan; Yang, Ke; Chang, Po-Ya; Ke, Der-Shin; Ko, Ying‐Chin

doi:10.1016/j.jhazmat.2010.01.118

Cited by 31 publications

(28 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is in agreement to our earlier studies where in we had reported the spermatotoxicity of the ethanolic extract of R. communis [6]. Similar spermatotoxicity was also observed in rats followed by the administration of areca nut extracts [19]. Only few studies have documented the spermatotoxicity of proteins.…”

Section: Discussionsupporting

confidence: 93%

Effects on spermatogenesis in swiss mice of a protein isolated from the roots of Ricinus communis (Linn.) (Euphorbiaceae)

Nithya

Anuja

Swathy

et al. 2011

Journal of Hazardous Materials

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 93%

Effects on spermatogenesis in swiss mice of a protein isolated from the roots of Ricinus communis (Linn.) (Euphorbiaceae)

Nithya

Anuja

Swathy

et al. 2011

Journal of Hazardous Materials

View full text Add to dashboard Cite

“…When referring to the testicular toxicity induced by arecoline, Wu et al [12] indicate that the administration of areca nut extracts have no impact on the weights of body and testis in rats but can induce spermatogenic damage and affect sperm counts and sperm motility. In contraction with their indications, we detect dominant changes in the body and testis weights except in the relative testis weight.…”

Section: Discussionmentioning

confidence: 99%

“…Besides, arecoline induced cytotoxic, genotoxic and immunotoxic effects are also well documented [8,9,10]. Interestingly, arecoline is demonstrated to induce hepatotoxicity and testicular toxicity both by generating reactive oxygen species (ROS) [11,12]. Several reports have implicated that excessive generation of these free radicals could result in oxidant stress and disturb antioxidant defense [13,14].…”

Section: Introductionmentioning

confidence: 99%

The Hepatotoxicity and Testicular Toxicity Induced by Arecoline in Mice and Protective Effects of Vitamins C and E

Zhou

Sun

Yang

et al. 2014

Korean J Physiol Pharmacol

View full text Add to dashboard Cite

Arecoline is a major alkaloid of areca nuts which are widely chewed by southeast Asian and it manifests various toxic effects in different organs of human and animals. In this work, mature mice were treated by vitamins C plus E, arecoline, or both daily for four weeks. The results showed that arecoline significantly increased the levels of serum alkaline phosphatase (ALP), glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT) and significantly decreased the levels of reduced glutathione (GSH), glutathione-S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT) in the liver tissues. Additionally, the body weight, testis weight, sperm counts, motility and normal sperms also were significantly decreased. The supplement of vitamins C and E can bring the activities of ALP and GPT to normal levels and partially restore the sperm counts compared to the arecoline-treated group but have no other positive effects. In conclusion, the vitamins C and E partially attenuated the arecoline-induced hepatotoxiciy but basically had on protective effects against the arecoline-induced testicular toxicity.

show abstract

“…Betel-quid use is associated with oral cancer, obesity, diabetes mellitus, hypertension, hyperlipidemia, liver cirrhosis, hepatocellular carcinoma, and spermatogenic damage (Tsai et al, 2004;Guh et al, 2006;Wu et al, 2010). Arecoline ( Fig.…”

Section: Introductionmentioning

confidence: 99%

Effects of arecoline on hepatic cytochrome P450 activity and oxidative stress

et al. 2014

View full text Add to dashboard Cite

-Betel-quid use is associated with the risk of liver cirrhosis and hepatocellular carcinoma. The aim of the present work was to evaluate the impact of arecoline on human hepatic cytochrome P450 (CYP) enzymes in vitro and rat hepatic CYP enzymes, as well as the hepatic oxidative stress and liver injury of rats in vivo. The in vitro results indicated that arecoline hydrobromide (AH) has no significant effect on the activities of CYP2B, 2C9, 3A4, 1A2, 2E1 and 2D6 in human liver microsome (HLM). However, oral administration of AH at 4 and 20 mg/kg/d for seven consecutive days significantly increased the activities of rat hepatic CYP2B, 2E1, 2D, 3A, 2C and 1A2. In addition, AH at 100 mg/kg/d significantly increased the levels of ALT, AST and MDA, decreased the levels of SOD, CAT, GSH-Px and GSH, in rat liver. The in vivo induction of AH on rat hepatic CYP isoforms suggested that the high risk of metabolic interaction should be existed when the substrate drugs of the six kinds of CYP isoforms was administered in betel-quid use human. Furthermore, the in vivo results also suggested that AH-induced hepatoxicity should be associated with the induction of AH on rat hepatic CYP2E1 and 2B.

show abstract

A characterization of the antioxidant enzyme activity and reproductive toxicity in male rats following sub-chronic exposure to areca nut extracts

Cited by 31 publications

References 29 publications

Effects on spermatogenesis in swiss mice of a protein isolated from the roots of Ricinus communis (Linn.) (Euphorbiaceae)

Effects on spermatogenesis in swiss mice of a protein isolated from the roots of Ricinus communis (Linn.) (Euphorbiaceae)

The Hepatotoxicity and Testicular Toxicity Induced by Arecoline in Mice and Protective Effects of Vitamins C and E

Effects of arecoline on hepatic cytochrome P450 activity and oxidative stress

Contact Info

Product

Resources

About