A chemiluminescent biosensor for ultrasensitive detection of adenosine based on target-responsive DNA hydrogel with Au@HKUST-1 encapsulation

Lin, Yanna; Sun, Yuanling; Dai, Yuxue; Sun, Wei; Zhu, Xiaodong; Líu, Hao; Han, Rui; Gao, Dandan; Luo, Chuannan

doi:10.1016/j.snb.2019.03.075

Cited by 53 publications

(29 citation statements)

References 44 publications

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“…When adenosine and hemin were present at the same time, the conformation change of adenosine aptamers resulted in hydrogel collapse and Au@HKUST-1 were released to generate signals. Meanwhile, the mimetic peroxidase formed by G-quadruplex catalyzes luminol to exhibit chemiluminescence [58].…”

Section: Target-responsive Nahsmentioning

confidence: 99%

Smart Nucleic Acid Hydrogels with High Stimuli-Responsiveness in Biomedical Fields

Zhang

Zhu

et al. 2022

IJMS

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Due to their hydrophilic, biocompatible and adjustability properties, hydrogels have received a lot of attention. The introduction of nucleic acids has made hydrogels highly stimuli-responsiveness and they have become a new generation of intelligent biomaterials. In this review, the development and utilization of smart nucleic acid hydrogels (NAHs) with a high stimulation responsiveness were elaborated systematically. We discussed NAHs with a high stimuli-responsiveness, including pure NAHs and hybrid NAHs. In particular, four stimulation factors of NAHs were described in details, including pH, ions, small molecular substances, and temperature. The research progress of nucleic acid hydrogels in biomedical applications in recent years is comprehensively discussed. Finally, the opportunities and challenges facing the future development of nucleic acid hydrogels are also discussed.

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Section: Target-responsive Nahsmentioning

confidence: 99%

Smart Nucleic Acid Hydrogels with High Stimuli-Responsiveness in Biomedical Fields

Zhang

Zhu

et al. 2022

IJMS

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“…Thus, DNA‐based hydrogels incorporated with aptamers provide ideal biorecognition elements for biosensors. [ 30 , 31 , 32 ] Furthermore, since the low molecular weight of aptamers promotes the probability of their excretion via blood, they are protected effectively from the degradation and delivered to the specific sites for the rapid and accurate identification of targets in vivo by being embedded on the scaffolds or being directly encapsulated into the hydrogels. Currently, aptamers are widely used for molecular detection and medical diagnosis.…”

Section: Functional Units and Their Assembly Strategies For Nahsmentioning

confidence: 99%

Smart and Functionalized Development of Nucleic Acid‐Based Hydrogels: Assembly Strategies, Recent Advances, and Challenges

et al. 2021

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Nucleic acid-based hydrogels that integrate intrinsic biological properties of nucleic acids and mechanical behavior of their advanced assemblies are appealing bioanalysis and biomedical studies for the development of new-generation smart biomaterials. It is inseparable from development and incorporation of novel structural and functional units. This review highlights different functional units of nucleic acids, polymers, and novel nanomaterials in the order of structures, properties, and functions, and their assembly strategies for the fabrication of nucleic acid-based hydrogels. Also, recent advances in the design of multifunctional and stimuli-responsive nucleic acid-based hydrogels in bioanalysis and biomedical science are discussed, focusing on the applications of customized hydrogels for emerging directions, including 3D cell cultivation and 3D bioprinting. Finally, the key challenge and future perspectives are outlined.

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“…Subsequently, adenosine was added which resulted in the complete dissolution of the DNA hydrogel. Then, G-quadruplex/hemin and Au@HKUST-1 were released that enabled the dual signal amplification of the biosensor [39].…”

Section: Dnazyme-based Dna Hydrogelsmentioning

confidence: 99%

DNA hydrogel-empowered biosensing

Khajouei

Ravan

Ebrahimi

2020

Advances in Colloid and Interface Science

100

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DNA hydrogels as special members in the DNA nanotechnology have provided crucial prerequisites to create innovative gels owing to their sufficient stability, biocompatibility, biodegradability, and tunable multifunctionality. These properties have tailored DNA hydrogels for various applications in drug delivery, tissue engineering, sensors, and cancer therapy. Recently, DNA-based materials have attracted substantial consideration for the exploration of smart hydrogels, in which their properties can change in response to chemical or physical stimuli. In other words, these gels can undergo switchable gel-to-sol or sol-to-gel transitions upon application of different triggers. Moreover, various functional motifs like i-motif structures, antisense DNAs, DNAzymes, and aptamers can be inserted into the polymer network to offer a molecular recognition capability to the complex. In this manuscript, a comprehensive discussion will be endowed with the recognition capability of different kinds of DNA hydrogels and the alternation in physicochemical behaviors upon target introducing. Finally, we offer a vision into the future landscape of DNA based hydrogels in sensing applications.

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A chemiluminescent biosensor for ultrasensitive detection of adenosine based on target-responsive DNA hydrogel with Au@HKUST-1 encapsulation

Cited by 53 publications

References 44 publications

Smart Nucleic Acid Hydrogels with High Stimuli-Responsiveness in Biomedical Fields

Smart Nucleic Acid Hydrogels with High Stimuli-Responsiveness in Biomedical Fields

Smart and Functionalized Development of Nucleic Acid‐Based Hydrogels: Assembly Strategies, Recent Advances, and Challenges

DNA hydrogel-empowered biosensing

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