A Chemotactic Colloidal Motor

Zhou, Chang; Yang, Ling; Wu, Yingjie; Yang, Mingcheng; He, Qiang

doi:10.1002/chem.202202319

Cited by 6 publications

(5 citation statements)

References 40 publications

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“…Modifying the surface of the self-propelled particles (the particles that consume energy from chemical substances for their movements) [111,112] with atom-size metallic species will be another attractive subject for the future development of atomically dispersed nanocatalysts. In case of single-atom-layer catalysts, it is necessary to provide correlations between the numbers of the atomic layers and the catalytic activity.…”

Section: Discussionmentioning

confidence: 99%

Atomically‐Dispersed Metal Heterocatalysts: A Practical Step Toward Sustainability

Vafaeezadeh,

Thiel

2023

ChemNanoMat

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Atomically‐dispersed heterogeneous metal catalysts can be considered as an “upgraded” version of classical solid metal catalysts. Unlike traditional heterogeneous metallic catalysts that contain nanoparticles or bulk micro‐sized transition metal species, the active sites of these novel types of catalysts are atomically distributed on the support’s surface. This provides several advantages compared to classical catalysts such as higher activity and need for just very small amounts of metal precursors for the catalyst preparation. The latter issue is a key point in green chemical processes and of importance to achieve low‐cost pathways for industrial‐scale synthesis. The atomically dispersed metal sites permit a maximum of metal dispersion and additionally allow to achieve more reproducible heterogeneous catalysts. This review summarizes an overview on breakthrough findings in synthesis, applications and characterization techniques developed in the area of single‐atom, dual‐atom, single‐atom‐layer, single‐site as well as single‐atom nanozyme/enzyme catalysis. The characteristics and properties of each system provide an appropriate understanding for designing a nanomaterial that is optimized for a specific requirement.

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Section: Discussionmentioning

confidence: 99%

Atomically‐Dispersed Metal Heterocatalysts: A Practical Step Toward Sustainability

Vafaeezadeh,

Thiel

2023

ChemNanoMat

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“…[ 15,51 ] The chemotaxis is ubiquitous in biology and can be easily achieved by establishing a non‐uniform reactant concentration gradient, which does not require expensive equipment and complex feed‐back regulation. [ 52 ] Thus, chemotaxis has been widely investigated. This part focuses on the design and biological applications of chemotactic MNMs, mainly involving catalytic and biohybrid MNMs ( Figure and Table 2 ).…”

Section: Design Strategies Of Biomedical Mnmsmentioning

confidence: 99%

“…Glucose activated chemotactic MNMs have been designed and the underlying mechanisms of chemotaxis have been experimentally revealed. [ 51a,52,65 ] By virtue of the catalysis of glucose oxidase (GOx) or cascade catalysis of GOx and CAT, chemotactic MNMs with different architectures were obtained, such as polymersome, polymer‐brush‐functionalized Janus gold (PNIPAM@JAu@GOx) nanomotor, and flask‐like colloidal motor. [ 12a,65,66 ] It was demonstrated that these MNMs could swim along the glucose gradient to reach the regions with higher glucose concentration, showing great potential in performing in vivo tasks.…”

Section: Design Strategies Of Biomedical Mnmsmentioning

confidence: 99%

Biomedical Micro‐/Nanomotors: Design, Imaging, and Disease Treatment

Liu

et al. 2023

Adv Funct Materials

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Untethered mobile micro-/nanomotors (MNMs), as newly-emerging attractive and versatile nanotechnologies, are expected to be the next-generation disease treatment tools, for breaking through the limitations of conventional passive drug delivery manner. However, the advances in these fascinating platforms have been hampered by the complexity of the biological environment and the particularity of disease microenvironment. Consequently, specific design strategies and clinical imaging techniques are essential to ensure the high-efficiency of biomedical MNMs on actuation, targeting, localization, and therapy when performing assigned in vivo tasks. This review thus comprehensively addresses three aspects of biomedical MNMs, including design, imaging, and disease treatment, highlighting the intelligent MNMs with biomimetic functionality and chemotactic capability, emphasizing the applicability of different imaging techniques, and focusing on various proofof-concept studies based on physiological characteristics for the treatment of major diseases. In addition, the key challenges and limitations of current biomedical MNMs are addressed, which may inspire future research and facilitate translation toward clinical treatment.

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“…The diminutive size, expansive surface area, and diverse functional attributes of micro/nanomotors (MNMs) confer a broad spectrum of applications and manipulation capabilities within microenvironmental interactions, nano-bio-interfaces, and cellular contexts [ 1 , 2 , 3 , 4 , 5 ]. Particularly in the biomedical field, intelligent MNMs have the potential to revolutionize drug delivery, cancer treatment, and in vivo imaging [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Strategic Structural Control of Polyserotonin Nanoparticles and Their Application as pH-Responsive Nanomotors

Hu,

Cao,

Lin

et al. 2024

Nanomaterials

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Serotonin-based nanomaterials have been positioned as promising contenders for constructing multifunctional biomedical nanoplatforms due to notable biocompatibility, advantageous charge properties, and chemical adaptability. The elaborately designed structure and morphology are significant for their applications as functional carriers. In this study, we fabricated anisotropic bowl-like mesoporous polyserotonin (PST) nanoparticles with a diameter of approximately 170 nm through nano-emulsion polymerization, employing P123/F127 as a dual-soft template and 1,3,5-trimethylbenzene (TMB) as both pore expander and emulsion template. Their formation can be attributed to the synchronized assembly of P123/F127/TMB, along with the concurrent manifestation of anisotropic nucleation and growth on the TMB emulsion droplet surface. Meanwhile, the morphology of PST nanoparticles can be regulated from sphere- to bowl-like, with a particle size distribution ranging from 432 nm to 100 nm, experiencing a transformation from a dendritic, cylindrical open mesoporous structure to an approximately non-porous structure by altering the reaction parameters. The well-defined mesopores, intrinsic asymmetry, and pH-dependent charge reversal characteristics enable the as-prepared mesoporous bowl-like PST nanoparticles’ potential for constructing responsive biomedical nanomotors through incorporating some catalytic functional materials, 3.5 nm CeO2 nanoenzymes, as a demonstration. The constructed nanomotors demonstrate remarkable autonomous movement capabilities under physiological H2O2 concentrations, even at an extremely low concentration of 0.05 mM, showcasing the 51.58 body length/s velocity. Furthermore, they can also respond to physiological pH values ranging from 4.4 to 7.4, exhibiting reduced mobility with increasing pH. This charge reversal-based responsive nanomotor design utilizing PST nanoparticles holds great promise for advancing the application of nanomotors within complex biological systems.

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A Chemotactic Colloidal Motor

Cited by 6 publications

References 40 publications

Atomically‐Dispersed Metal Heterocatalysts: A Practical Step Toward Sustainability

Atomically‐Dispersed Metal Heterocatalysts: A Practical Step Toward Sustainability

Biomedical Micro‐/Nanomotors: Design, Imaging, and Disease Treatment

Strategic Structural Control of Polyserotonin Nanoparticles and Their Application as pH-Responsive Nanomotors

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