A child-friendly anti-infective gummy formulation: Design, physicochemical, micromechanical, and taste sensory evaluation

Leading Paediatric Infectious Diseases—Current Trends, Gaps, and Future Prospects in Oral Pharmacotherapeutic Interventions

“…Tuberculosis (TB) continues to be a major cause of sickness and death in children and adults globally [ 164 , 165 ]. TB is one of the oldest infectious diseases known to afflict humans and is brought on by Mycobacterium tuberculosis ( Mtb ) [ 165 ]. Approximately 7.5 million children are infected with Mtb .…”

“…Despite being preventable and/or treatable, more than one million children (under 15 years of age) and half a million adolescents aged 15–19 get sick from TB yearly. Children are particularly susceptible to TB transmission, and it is one of the leading causes of death in the paediatric population with about 205,000 minors dying per annum (excluding HIV-negative children) [ 165 , 166 , 167 ]. In the case of pulmonary TB (PTB), this usually manifest as a combination of one or more of the following symptoms: extended coughs (often lasting longer than 3 weeks with or without sputum production), coughing up blood, chest pain, loss of appetite, unexpected weight loss, night sweats, fever, and fatigue.…”

“…In the case of pulmonary TB (PTB), this usually manifest as a combination of one or more of the following symptoms: extended coughs (often lasting longer than 3 weeks with or without sputum production), coughing up blood, chest pain, loss of appetite, unexpected weight loss, night sweats, fever, and fatigue. In the case of extrapulmonary TB (i.e., TB developing outside the lungs), presenting symptoms will often be dictated by the part of the body affected, although some symptoms such as loss of appetite, night sweat, and fever may be more general [ 165 , 168 , 169 ].…”