A Child With Antibodies Targeting Both Linear IgA Bullous Dermatosis and Bullous Pemphigoid Antigens

“… 10–12 IgG reactivity to BP180 was also detected in six of nine sera from the patients with CP, which extends previous observations. 13 Surprisingly, six of 10 LABD sera contained IgG reactive with BP180, a finding described so far only in a subset of patients with a clinical picture resembling LABD but exhibiting deposits of both IgG and IgA at the BM of lesional skin 25,26 . This condition has therefore been classified as linear IgA/IgG bullous dermatosis (LAGBD) 25,26 .…”

Section: Discussionmentioning

confidence: 99%

IgG, IgA and IgE autoantibodies against the ectodomain of BP180 in patients with bullous and cicatricial pemphigoid and linear IgA bullous dermatosis

Christophoridis

Büdinger

Borradori

et al. 2000

British Journal of Dermatology

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The presence of IgG and IgA autoantibody responses to BP180 in patients with three clinically distinct autoimmune bullous diseases indicates that an autoimmune response to the same distinct adhesion protein may lead to different clinical manifestations. It is therefore conceivable that variable epitopes of BP180 are targeted by the different autoantibody isotypes, resulting in the distinct clinical pictures.

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“…Cases of LABD with IgG antibodies in addition to IgA antibodies deposited in a linear fashion at the BMZ have been reported. 18−23 These cases immunopathologically represent an overlap of LABD and BP. These patients do not meet the strict criteria for the definition of LABD needed for the research setting.…”

Section: Immunopathologymentioning

confidence: 99%