A Chinese classical prescription Guizhi-Fuling Wan in treatment of ovarian cancer: An overview

Wang, XueZhen; Su, PeiWei; Hao, Quan; Zhang, Xiaoyu; Xia, L.; Zhang, Yanan

doi:10.1016/j.biopha.2022.113401

Cited by 15 publications

(3 citation statements)

References 39 publications

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“…[4,16] Modern pharmacological studies have demonstrated that GFP exhibits significant anti-inflammatory, anticancer, anticoagulant, neuroregulatory, metabolic regulatory, and immunomodulatory effects. [16,20,21] In this study, utilizing network pharmacology and constructing a network of Chinese herbal compound regulation, we identified 6 key component nodes with the closest associations to cardiovascular diseases among the top 10 active components ranked by degree. These components, ranked in descending order of degree value, include quercetin, beta-sitosterol, baicalein, kaempferol, cerevisterol, and albiflorin, suggesting their potential crucial roles in the treatment of CSA.…”

Section: Discussionmentioning

confidence: 99%

Exploring the mechanisms of Guizhifuling pills in the treatment of coronary spastic angina based on network pharmacology combined with molecular docking

Xu,

Cui,

Zhang

et al. 2024

Medicine

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Coronary spastic angina (CSA) is common, and treatment options for refractory vasospastic angina are sometimes limited. Guizhifuling pills (GFP) have demonstrated efficacy in reducing CSA episodes, but their pharmacological mechanism remains unclear. To explore the mechanism of action of GFP in preventing and treating CSA, we employed network pharmacology and molecular docking to predict targets and analyze networks. We searched GFP chemical composition information and related targets from databases. The drug-target and drug-target pathway networks were constructed using Cytoscape. Then the protein–protein interaction was analyzed using the STRING database. Gene Ontology biological functions and Kyoto Encyclopedia of Genes and Genomes pathways were performed by the Metascape database, and molecular docking validation of vital active ingredients and action targets of GFP was performed using AutoDock Vina software. The 51 active components in GFP are expected to influence CSA by controlling 279 target genes and 151 signaling pathways. Among them, 6 core components, such as quercetin, β-sitosterol, and baicalein, may regulate CSA by affecting 10 key target genes such as STAT3, IL-6, TP53, AKT1, and EGFR. In addition, they are involved in various critical signaling pathways such as apelin, calcium, advanced glycation end product–receptor for advanced glycation end product, and necroptosis. Molecular docking analysis confirms favorable binding interactions between the active components of GFP and the selected target proteins. The effects of GFP in treating CSA involve multiple components, targets, and pathways, offering a theoretical basis for its clinical use and enhancing our understanding of how it works.

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Section: Discussionmentioning

confidence: 99%

Exploring the mechanisms of Guizhifuling pills in the treatment of coronary spastic angina based on network pharmacology combined with molecular docking

Xu,

Cui,

Zhang

et al. 2024

Medicine

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“…With the rise of targeted therapies and immunotherapy, poly (ADP-ribose) polymerase inhibitors, epidermal growth factor receptor and anti-angiogenesis inhibitors have been widely used in terms of maintenance therapy ( 9 ). Furthermore, an increasing number of researchers have shifted their attention to herbal medicines and natural compound extracts; for example, a recently published study by Wang et al ( 10 ) explored the anti-OC mechanism of the classic Chinese herbal formula ‘Guizhi Fuling Wan’, which was found to achieve antitumor effects through inducing apoptosis, inhibiting cancer cell proliferation and enhancing immunotherapy sensitivity.…”

Section: Ocmentioning

confidence: 99%

Advance in vasculogenic mimicry in ovarian cancer (Review)

Tian,

Si,

Liu

et al. 2023

Oncol Lett

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Ovarian cancer (OC) is a common and highly prevalent malignant tumor in women, associated with a high mortality rate, easy recurrence and easy metastasis, which is predominantly at an advanced stage when detected in patients. This renders the cancer more difficult to treat, and consequently it is also associated with a low survival rate, being the malignancy with the highest mortality rate among the various gynecological tumors. As an important factor affecting the development and metastasis of OC, understanding the underlying mechanism(s) through which it is formed and developed is crucial in terms of its treatment. At present, the therapeutic methods of angiogenic mimicry for OC remain in the preliminary stages of exploration and have not been applied in actual clinical practice. In the present review, various signaling pathways and factors affecting angiogenic mimicry in OC were described, and the chemical synthetic drugs, natural compound extracts, small-molecule protein antibodies and their associated targets, and so on, that target angiogenic mimicry in the treatment of OC, were discussed. The purpose of this review was to provide new research ideas and potential theoretical support for the discovery of novel therapeutic targets for OC that may be applied in the clinic, with the aim of effectively reducing its metastasis and recurrence rates. Contents1. Introduction 2. Ovarian cancer 3. Vasculogenic mimicry (VM) 4. Signaling pathways associated with angiogenic mimicry in OC 5. OC angiogenesis mimetic-associated inhibitors 6.

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“…(PS), Prunus perisica (L.) Batsch (PP) [ 8 ] and major compounds including cinnamaldehyde, cinnamic acid, paeoniflorin and paeonol [ 9 ]. GFW has mainly been used to treat gynecological diseases for thousands of years and is used for various gynecological conditions in modern clinical practice, such as primary dysmenorrhea [ 10 ] and uterine fibroids [ 11 ], cervical cancer [ 12 ], and ovarian cancer [ 13 ]. No paper reports the protective effects of TCM from the formula, to its component herbs and the major compounds in one study.…”

Section: Introductionmentioning

confidence: 99%

Protection of Gueichih-Fuling-Wan on cerebral ischemia-induced brain injury in rodents is mediated by trans-cinnamaldehyde via inhibition of neuroinflammation and apoptosis

Chen,

Wu,

Kuo

et al. 2024

BioMedicine

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Background Stroke is the leading cause of mortality and morbidity worldwide, and an effective therapeutic strategy for the prevention of patients with cerebral ischemia induced brain injury is lacking. Traditional Chinese medicine with neuroprotective activities might be beneficial and provide alternative therapeutic opportunities for cerebral ischemia. Purposes This study aimed to evaluate the neuroprotection and possible mechanisms of Gueichih-Fuling-Wan (GFW), its’ constitutive herbs, and their active compounds on cerebral ischemia/reperfusion (I/R)-induced brain injury in rodents. Methods Various doses of extracts (0.25, 0.5, and 1.0 g/kg) of GFW and five constituent herbs ( Cinnamomi Cortex , CC; Poria cocos , PC; Paeonia lactifloa , PL; Paeonia suffruticosa , PS and Prunus perisica , PP) were orally administered. Different doses of active compounds (0.5, 1.0, and 2.0 mg/kg) of GFW such as cinnamaldehyde, cinnamic acid (from CC), paeoniflorin (from PL), and paeonol (from PS) were intraperitoneally administered. Their effects on cerebral ischemia/ reperfusion (I/R)induced brain injury in rodents were evaluated. Results GFW, its’ constituent herbs, and the active compounds reduced the infarct area dose-dependently (***P < 0.001). Cinnamaldehyde showed the most significant reduction (***P < 0.001). Therefore, trans-cinnamaldehyde (TCA) was further used to evaluate the neuroprotective mechanism of the I/R-induced brain injury. TCA (10, 20, 30 mg/ kg, p.o.) showed an inhibitory effect of I/R-induced brain damage in mice in a dose-dependent manner. Besides, GFW and TCA dose-dependently reduced the COX-2 protein expression level, and TCA reduced the TUNEL (+) apoptosis. TCA dose-dependently increased the pro-survival NR2A and Bcl-2 protein expression level and decreased the pro-apoptotic NR2B and cytochrome c , caspase 9, and caspase 3 expression (***P < 0.001). Conclusion The above data revealed that GFW, its’ constituent herbs, and active compounds protected against I/R-induced brain injury in rodents. TCA from CC might participate in GFW protecting against cerebral ischemia-induced brain injury by inhibiting neuroinflammation and apoptosis.

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A Chinese classical prescription Guizhi-Fuling Wan in treatment of ovarian cancer: An overview

Cited by 15 publications

References 39 publications

Exploring the mechanisms of Guizhifuling pills in the treatment of coronary spastic angina based on network pharmacology combined with molecular docking

Exploring the mechanisms of Guizhifuling pills in the treatment of coronary spastic angina based on network pharmacology combined with molecular docking

Advance in vasculogenic mimicry in ovarian cancer (Review)

Protection of Gueichih-Fuling-Wan on cerebral ischemia-induced brain injury in rodents is mediated by trans-cinnamaldehyde via inhibition of neuroinflammation and apoptosis

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