A Chiral Voltammetric Sensor Based on a Paste Electrode Modified by Cyanuric Acid for the Recognition and Determination of Tyrosine Enantiomers

Zilberg, R. A.; Maistrenko, V. N.; Kabirova, L. R.; Gus’kov, V. Yu.; Khamitov, E. M.; Дубровский, Давид Израилевич

doi:10.1134/s1061934820010189

Cited by 19 publications

(5 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several types of electrodes have been reported for Tyr monitoring, [1,[8][9][10][11][12][13][14][15][16][17][18][19] as described in Table S1. Although most works presented low LODs and a wide linear range, they require various chemicals to functionalize/modify the electrode surfaces.…”

Section: Comparison Of the Proposed Methods With Other Electrochemica...mentioning

confidence: 99%

“…For this purpose, electrochemical sensors can be an important tool for Tyr determination due to their attractive properties, such as high sensitivity, cost-effectiveness reliable, quick response, simple sample preparation, and enable in-situ analysis. Currently, some research groups reported the need for surface modification of electrodes to detect Tyr, [1,[8][9][10][11][12][13][14][15][16][17][18][19] however, they take several hours to be prepared and can produce chemical residues due to the material used for the electrode functionalization.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Infrared Laser‐Induced Graphene Sensor for Tyrosine Detection

et al. 2022

View full text Add to dashboard Cite

In this work, we demonstrate that laser‐induced graphene (LIG) electrodes produced by a single‐step infrared irradiation on a commercially available polyimide sheet work as portable platforms for the electrochemical detection of tyrosine (Tyr). The LIG surface was characterized by Raman and scanning electron microscopy, which confirmed the formation of graphene with a highly porous structure. The sensor associated with differential‐pulse voltammetry provided the determination of Tyr with a linear range between 5 and 30 μmol L−1, a limit of detection (LOD) of 1.5 μmol L−1, precision of 6.2 % (n=10), and a satisfying selectivity towards interfering species found in biological media (e. g., dopamine, urea, and both ascorbic and uric acids). Artificial urine samples spiked with different amounts were analyzed by the proposed sensor and recovery values between 107 and 114 % were obtained. Opposite to many works reported in the literature, this platform did not require costly and time‐consuming surface modification processes, being an alternative feasible for other applications of clinical/medical interest. One LIG electrode sensor is produced in 140 s without chemical waste generation.

show abstract

Section: Comparison Of the Proposed Methods With Other Electrochemica...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Infrared Laser‐Induced Graphene Sensor for Tyrosine Detection

et al. 2022

View full text Add to dashboard Cite

show abstract

“…For the present study, Tyr was selected to be detected from pharmaceutical products, as it is one of the non-essential AAs of the human body that is used to synthesize proteins, and when insufficient amounts are ingested, the body undergoes a series of changes at the level of the central nervous system [ 11 ]. Tyr has two isomers: L-Tyr and D-Tyr, synthesized in vivo from the essential AA L-Phe [ 12 ]. The WHO stresses a recommended daily intake of Tyr and Phe of 25 mg/kg body weight [ 13 ], showing that an increased level of Tyr can lead to fits of depression [ 14 ], Parkinson’s [ 15 ], and emotional disorders, and a low level to phenylketonuria (PKU) [ 16 , 17 ], albinism [ 18 ], and alkaptonuria [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Quantification of Tyrosine in Pharmaceuticals with the New Biosensor Based on Laccase-Modified Polypyrrole Polymeric Thin Film

Dinu¹,

Apetrei²

2022

Polymers

View full text Add to dashboard Cite

Stress, a state of body tension, sometimes caused by increased levels of tyrosine (Tyr) in the body, can lead to serious illnesses such as depression, irritability, anxiety, damage to the thyroid gland, and insomnia. The body can be provided with an adequate concentration of tyrosine by taking pharmaceutical products or by dietary intake. Therefore, this study presents the development of a new enzyme sensor for the quantification of Tyr in pharmaceuticals. A screen-printed carbon electrode (SPCE) was modified with the conductive polymer (CP) polypyrrole (PPy) doped with hexacyanoferrate (II) anion (FeCN), the polymer having been selected for its excellent properties, namely, permeability, conductivity, and stability. The enzyme laccase (Lacc) was subsequently immobilized in the polymer matrix and cross-linked with glutaraldehyde, as this enzyme is a thermostable catalyst, greatly improving the performance of the biosensor. The electrochemical method of analysis of the new device, Lacc/PPy/FeCN/SPCE, was cyclic voltammetry (CV), and chronoamperometry (CA) contributed to the study of changes in the biosensor with doped PPy. CV measurements confirmed that the Lacc/PPy/FeCN/SPCE biosensor is a sensitive and efficient platform for Tyr detection. Thus, this enzyme sensor showed a very low limit of detection (LOD) of 2.29 × 10−8 M, a limit of quantification (LOQ) of 7.63 × 10−8 M, and a very high sensitivity compared to both devices reported in the literature and the PPy/FeCN/SPCE sensor. Quantitative determination in pharmaceuticals was performed in L-Tyr solution of different concentrations ranging from 0.09 to 7 × 10−6 M. Validation of the device was performed by infrared spectrometry (FT-IR) on three pharmaceuticals from different manufacturers and with different Tyr concentrations.

show abstract

“…[14][15][16][17][18][19] It is well known that a chiral modifier is the key component for building an electrode's chiral surface for creating high enantioselectivity (ϑ) for selected analytes. 19 The majority of methods (except for molecular imprinting [20][21][22][23][24][25][26] ) use one or more chiral components [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] as modifiers for building a chiral layer on the electrode surface (Scheme 1). Obviously, the value of enantioselectivity depends on the structure of the modifier, and for any chiral analyte, the corresponding "complementary" modifier exists that provides the best enantioselectivity (Scheme 2).…”

Section: Introductionmentioning

confidence: 99%

“…The majority of methods (except for molecular imprinting 20–26 ) use one or more chiral components 27–44 as modifiers for building a chiral layer on the electrode surface (Scheme 1). Obviously, the value of enantioselectivity depends on the structure of the modifier, and for any chiral analyte, the corresponding “complementary” modifier exists that provides the best enantioselectivity (Scheme 2).…”

Section: Introductionmentioning

confidence: 99%

Rational design of highly enantioselective composite voltammetric sensors using a computationally predicted chiral modifier

et al. 2022

View full text Add to dashboard Cite

The use of chiral modifiers is among the simplest and most popular strategies for synthesizing enantioselective voltammetric sensors that are applied for the analysis and discrimination of enantiomerical drugs in various media. The type and structure of the chiral modifier are the key factors for the creation of enantioselectivity to a specified analyte. We suggest a novel approach to the prediction of the quality of a chiral modifier for preparing highly enantioselective sensors. The suggested approach is based on the molecular mechanics modeling of the adsorption of analyte enantiomers on chiral modifiers and on the comparison of the corresponding adsorption energies (ΔEads). The efficiency of our approach is demonstrated using the example of cyclodextrins and chiral single‐wall carbon nanotubes as chiral modifiers, and a wide range of chiral analytes. We found that the experimental enantioselectivity (ϑexp) measured using voltammetry linearly correlates with ΔEads. The suggested approach also showed good predictive power in application to enantioselective chromatography, which further validates its general applicability.

show abstract

A Chiral Voltammetric Sensor Based on a Paste Electrode Modified by Cyanuric Acid for the Recognition and Determination of Tyrosine Enantiomers

Cited by 19 publications

References 66 publications

Infrared Laser‐Induced Graphene Sensor for Tyrosine Detection

Infrared Laser‐Induced Graphene Sensor for Tyrosine Detection

Quantification of Tyrosine in Pharmaceuticals with the New Biosensor Based on Laccase-Modified Polypyrrole Polymeric Thin Film

Rational design of highly enantioselective composite voltammetric sensors using a computationally predicted chiral modifier

Contact Info

Product

Resources

About