A chiroptical molecular sensor for ferrocene

Agnes, Marco; Nitti, Andrea; Griend, Douglas A. Vander; Dondi, Daniele; Merli, Daniele; Pasini, Dario

doi:10.1039/c6cc05937f

Cited by 51 publications

(28 citation statements)

References 26 publications

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“…After the lid switches its conformation to reposition its CÀHg roups,h owever,C ÀH···XÀCi nteractions cease to exist therebyr educing the stability and population of this diastereomer.W ith dynamic chirality and stereoselective recognition being intimately relatedy et difficult to elucidate, our mechanistic findings about elusive CÀH···XÀCi nteractions [33,34,37] guiding the process open aw ay for additionally investigating and harnessing these fascinating noncovalent contacts, rarely observed in solution. [24] In fact, twisted capsules described herein can now be used for developing novel chiroptical sensors, [38] stereoselective catalysts, [39] topological stereoisomers [40] and scavengers of toxic compounds [41] on which we plan to reporti nt he future.…”

Section: Resultsmentioning

confidence: 97%

Multivalent C−H⋅⋅⋅Cl/Br−C Interactions Directing the Resolution of Dynamic and Twisted Capsules

Pavlović

Liu

Güney

et al. 2019

Chemistry A European J

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Section: Resultsmentioning

confidence: 97%

Multivalent C−H⋅⋅⋅Cl/Br−C Interactions Directing the Resolution of Dynamic and Twisted Capsules

Pavlović

Liu

Güney

et al. 2019

Chemistry A European J

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“…Despite of classic chiroptical sensors used orthogonally in conditions of competitive analysis, nanoassemblies display good structural stability and enhanced optical activities and surface‐enhanced Raman scattering (SERS), which have great potential performance in the detection of dual classes of biomarkers . Based on the principles of multiple signal generation, we selected GO and Au nanoparticles as the electrical and optical materials, respectively, to develop an assembly sensor.…”

Section: Methodsmentioning

confidence: 99%

A Chiral‐Nanoassemblies‐Enabled Strategy for Simultaneously Profiling Surface Glycoprotein and MicroRNA in Living Cells

et al. 2017

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Assemblies of nanomaterials for biological applications in living cells have attracted much attention. Herein, graphene oxide (GO)-gold nanoparticle (Au NP) assemblies are driven by a splint DNA strand, which is designed with two regions at both ends that are complementary with the DNA sequence anchored on the surface of the GO and the Au NPs. In the presence of microRNA (miR)-21 and epithelial cell-adhesion molecule (EpCAM), the hybridization of miR-21 with a molecular probe leads to the separation of 6-fluorescein-phosphoramidite-modified Au NPs from GO, resulting in a decrease in the Raman signal, while EpCAM recognition reduces circular dichroism (CD) signals. The CD signals reverse from negative in original assemblies into positive when reacted with cells, which correlates with two enantiomer geometries. The EpCAM detection has a good linear range of 8.47-74.78 pg mL and a limit of detection (LOD) of 3.63 pg mL , whereas miR-21 detection displays an outstanding linear range of 0.07-13.68 amol ng and LOD of 0.03 amol ng . All the results are in good agreement with those of the Raman and confocal bioimaging. The strategy opens up an avenue to allow the highly accurate and reliable diagnosis (dual targets) of clinic diseases.

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“…Absorption, fluorescence, and Raman scattering have been used as biosensors for many years . Typically, the chiroptical organic molecular compounds have been investigated for different systems, and can be applied for monitoring of absolute configuration, enantiomeric excess for small molecule targets . These developed chiral probes produce distinct CD signal upon against targets (amino alcohols, ferrocene, monoamines, etc.)…”

Section: The Applications In Chirality‐based Biosensorsmentioning

confidence: 99%

Chirality‐Based Biosensors

Wang

et al. 2018

Adv Funct Materials

123

120

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The fabrication of chiral nanostructures gives rise to characteristic chiroptical activity, which can be used for chirality-based biosensors. Great progress is made in the use of nanoassemblies for the construction of chiral nanoparticle dimers, pyramids, helices, and twisted structures, and their chiroptical activities correlate with diverse structural geometries and enantiomeric configurations. In DNA-hybridization-based chiral nanoassemblies, the assembly parameters, such as the components, gaps, multicomponents, and the aftergrowth of metal, can result in multiple bands and enhanced chiroptical effects. Based on known chiral nanostructures, the existing chiral nanoassembly-based biosensors together with their targets and signal amplification strategies are reviewed. Chirality involves multiple signals, and multitarget biosensors are introduced with newly developed chiral architectures for the accurate and reliable monitoring of biomarkers in living cells. The interactions between chiral nanoarchitectures and biosystems are also highlighted, which are important not only in the chiral dynamic switching of nano-objects for biomonitoring, but also in manipulating cell growth, proliferation, and adhesion. The future perspectives on chiral fabrication and its use in biosensors are also comprehensively discussed. and future perspectives in chiral fabrication to enhance the chiroptical properties for emerging biosensors application.

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A chiroptical molecular sensor for ferrocene

Cited by 51 publications

References 26 publications

Multivalent C−H⋅⋅⋅Cl/Br−C Interactions Directing the Resolution of Dynamic and Twisted Capsules

Multivalent C−H⋅⋅⋅Cl/Br−C Interactions Directing the Resolution of Dynamic and Twisted Capsules

A Chiral‐Nanoassemblies‐Enabled Strategy for Simultaneously Profiling Surface Glycoprotein and MicroRNA in Living Cells

Chirality‐Based Biosensors

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