A cholera-like illness in a traveller due to a mixed infection with enterotoxigenic Escherichia coli, vibrio parahaemolyticus and Pseudomonas aeruginosa

Bockemühl, J; Fleischer, K; Bednarek, Ilona

doi:10.1007/bf01641260

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…Although we do not yet know how often different V. cholerae strains compete within human hosts, it is clear that infections always involve multiple species. These include other pathogenic genera, such as Pseudomonas , Salmonella , and Campylobacter [ 54 , 55 ], and there is compelling evidence that V. cholerae must compete with native intestinal microbial fauna in order to become established [ 56 ]. Furthermore, EPS secretion appears to be important for within-biofilm competition: quorum-sensing–deficient V. cholerae mutants that overproduce EPS take over biofilm cultures coinoculated with wild-type bacteria [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

The Evolution of Quorum Sensing in Bacterial Biofilms

et al. 2008

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Bacteria have fascinating and diverse social lives. They display coordinated group behaviors regulated by quorum-sensing systems that detect the density of other bacteria around them. A key example of such group behavior is biofilm formation, in which communities of cells attach to a surface and envelope themselves in secreted polymers. Curiously, after reaching high cell density, some bacterial species activate polymer secretion, whereas others terminate polymer secretion. Here, we investigate this striking variation in the first evolutionary model of quorum sensing in biofilms. We use detailed individual-based simulations to investigate evolutionary competitions between strains that differ in their polymer production and quorum-sensing phenotypes. The benefit of activating polymer secretion at high cell density is relatively straightforward: secretion starts upon biofilm formation, allowing strains to push their lineages into nutrient-rich areas and suffocate neighboring cells. But why use quorum sensing to terminate polymer secretion at high cell density? We find that deactivating polymer production in biofilms can yield an advantage by redirecting resources into growth, but that this advantage occurs only in a limited time window. We predict, therefore, that down-regulation of polymer secretion at high cell density will evolve when it can coincide with dispersal events, but it will be disfavored in long-lived (chronic) biofilms with sustained competition among strains. Our model suggests that the observed variation in quorum-sensing behavior can be linked to the differing requirements of bacteria in chronic versus acute biofilm infections. This is well illustrated by the case of Vibrio cholerae, which competes within biofilms by polymer secretion, terminates polymer secretion at high cell density, and induces an acute disease course that ends with mass dispersal from the host. More generally, this work shows that the balance of competition within and among biofilms can be pivotal in the evolution of quorum sensing.

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Section: Discussionmentioning

confidence: 99%

The Evolution of Quorum Sensing in Bacterial Biofilms

et al. 2008

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“…Jertborn and Svennerholm [13] have discovered enterotoxin-producing Pseudomonas in Swedish travellers with diarrhoea, somewhat more frequently in travellers visiting Africa, Asia and Latin America. In association with other bacteria they can cause severe cholera symptoms in healthy adults [14]. Even when their enterotoxigenic activity is weak they can still produce diarrhoea in immunodeficient individuals [15].…”

Section: Introductionmentioning

confidence: 99%

Genetic Detection of Pseudomonas spp. in Commercial Amazonian Fish

Ardura

Linde

García‐Vázquez

2013

IJERPH

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Brazilian freshwater fish caught from large drainages like the River Amazon represent a million ton market in expansion, which is of enormous importance for export to other continents as exotic seafood. A guarantee of bacteriological safety is required for international exports that comprise a set of different bacteria but not any Pseudomonas. However, diarrhoea, infections and even septicaemia caused by some Pseudomonas species have been reported, especially in immune-depressed patients. In this work we have employed PCR-based methodology for identifying Pseudomonas species in commercial fish caught from two different areas within the Amazon basin. Most fish caught from the downstream tributary River Tapajòs were contaminated by five different Pseudomonas species. All fish samples obtained from the River Negro tributary (Manaus markets) contained Pseudomonas, but a less diverse community with only two species. The most dangerous Pseudomonas species for human health, P. aeruginosa, was not found and consumption of these fish (from their Pseudomonas content) can be considered safe for healthy consumers. As a precautionary approach we suggest considering Pseudomonas in routine bacteriological surveys of imported seafood.

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Verarbeitung von klinischen Materialien und Bedeutung der Erregerspektren von Krankheitsbildern für die Diagnostik

Werk¹

1990

Medizinische Bakteriologie Und Infektiologie

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A cholera-like illness in a traveller due to a mixed infection with enterotoxigenic Escherichia coli, vibrio parahaemolyticus and Pseudomonas aeruginosa

Cited by 5 publications

References 13 publications

The Evolution of Quorum Sensing in Bacterial Biofilms

The Evolution of Quorum Sensing in Bacterial Biofilms

Genetic Detection of Pseudomonas spp. in Commercial Amazonian Fish

Verarbeitung von klinischen Materialien und Bedeutung der Erregerspektren von Krankheitsbildern für die Diagnostik

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