A chromatography-free one-pot, two-step synthesis of 1,2,4-thiadiazoles from primary amides via thiolation and oxidative dimerization under solvent-free conditions: a greener approach

Abstract

Synthesis of 1,2,4-thiadiazoles using Lawesson's reagent and TBHP via thiolation and oxidative dimerization of primary amides. This versatile and efficient method demonstrates excellent tolerance for various functional groups in amides.