A chromosome study of three ovarian tumors

Chromosome abnormalities of eighty-one pediatric germ cell tumors: Sex-, age-, site-, and histopathology-related differences?a Children's Cancer Group study

“…The three benign teratomas with abnormalities had simple numeric gains, again similar to the adult counterparts. Benign ovarian teratomas from adults show gains of 3 and 8 to be common (Ihara et al, 1983;Jenkyn and McCartney, 1987;Yang-Feng et al, 1988;Dahl et al, 1990;Surti et al, 1990). Two of the three cases with chromosome abnormalities in our series exhibited either ϩ3 or ϩ8.…”

Chromosome 12p abnormalities in dysgerminoma of the ovary: a FISH analysis

“…Jenkyn and McCartney 17 reported the results of karyotypic analyses on three different types of malignant ovarian tumors, and i(12p) was detected on ascitic fluid cells from a 19-year-old girl with dysgerminoma. At the same time, Atkin and Baker demonstrated the presence of i(12p) as a peculiar genetic abnormality in one dysgerminoma.…”

Loss of heterozygosity and amplification on chromosome 11q in human ovarian cancer

“…(Figure 4). A number of cytogenetic reports in ovarian tumours have noted the consistent, but infrequent finding of translocations and deletions involving l1q23-q25 (Jenkyn & McCartney, 1987;Pejovic et al, 1989;Bello & Ray, 1990;Pejovic et al, 1992). Interestingly, a translocation t(I;ll)(q25;q23) was seen as the only karyotypic abnormality in a mucinous cystadenoma (Pejovic et al, 1990), suggesting that such translocations may be significant early events in the pathogenesis of malignant ovarian neoplasia.…”