A chronic high fat diet alters the homologous and heterologous control of appetite regulating peptide receptor expression

Changes of Bladder M1,3 Muscarinic Receptor Expression in Rats Fed with Short‐Term/Long‐Term High‐Fat Diets

“…In mice, HFD induced changes in the plasma levels of these peptides and altered the expression of the receptors on vagal afferents. 18 Thus the detrimental effects of HFD on bladder function can perpetuate and progress with time as shown in our results.…”

“…On the other hand, leptin, ghrelin and neuropeptide W can regulate eating habits through modulation of vagal afferent activity and gastrointestinal motility. In mice, HFD induced changes in the plasma levels of these peptides and altered the expression of the receptors on vagal afferents . Thus the detrimental effects of HFD on bladder function can perpetuate and progress with time as shown in our results.…”

Plasticity of gastrointestinal vagal afferent satiety signals

“…In addition, there is significant interaction between gut hormones. For example, in cultured vagal afferent neurons, exposure to leptin or ghrelin changed the expression of not only their own receptor but also that of other appetite hormone receptors . This complex interplay presumably allows for the fine control of food intake to meet metabolic demand.…”

High fat diet induced changes in gastric vagal afferent response to adiponectin

“…The expression of adiponectin receptors is linked to metabolic status with abundance inversely proportional to circulating insulin levels [28]. The nodose ganglia (NDG) containing the cell bodies of vagal afferents incorporate a variety of receptors for peptides with food intake modulatory effects such as leptin, ghrelin and cholecystokinin [29]. The presence of adiponectin receptors in vagal afferents has not previously been reported and there are also no prior reports, as far as can be determined, as to whether a peripheral vagal pathway exists for adiponectin and whether any potential GVA signaling is disrupted in obesity where circulating adiponectin concentrations have been suggested to be decreased.…”