A Chronic Illness Characterized by Fatigue, Neurologic and Immunologic Disorders, and Active Human Herpesvirus Type 6 Infection

Abstract

Neurologic symptoms, MRI findings, and lymphocyte phenotyping studies suggest that the patients may have been experiencing a chronic, immunologically mediated inflammatory process of the central nervous system. The active replication of HHV-6 most likely represents reactivation of latent infection, perhaps due to immunologic dysfunction. Our study did not directly address whether HHV-6, a lymphotropic and gliotropic virus, plays a role in producing the symptoms or the immunologic and neurologic dysfunction seen in this illness. Whether the findings in our patients, who came from a relatively small geographic area, will be generalizable to other patients with a similar syndrome remains to be seen.

Neurobiological aspects of the chronic fatigue syndrome

“…Buchwald ei at. [69] did magnetic resonance scans on a series of patients involved in the 'Lake Tahoe' epidemic. Seventy-eight percent of patients had punctate, sub-cortical areas of high signal intensity.…”

A cerebralização da fadiga: uma análise da hipótese cerebral no caso da síndrome da fadiga crônica

“…4 There is an extensive bibliography regarding utilization of neuroimaging methods in the case of CFS and new studies on the topic are being incessantly produced. To understand some of the paths and results in this field, see Buchwald et al, 1992;Schwartz et al, 1994;Costa, Tannock, Brostoff, 1995;Greco et al, 1997;Tirelli et al, 1998;Lange et al, 1999;Cook et al, 2001;and Schmaling et al, 2003. 5 The problem of cerebral types is also analyzed by Ortega (2009), in a study on the autistic neurodiversity movement.…”

“…The first study using magnetic resonance imaging was conducted by Buchwald et al (1992) and told of abnormalities in 78% of the 144 patients included in the study focused Francisco Ortega, Rafaela Zorzanelli on the Lake Tahoe epidemic in Nevada, compared with the 21% found in the control subjects. It should be pointed out that these alterations were, for the most part, more intense bright spots that seemed abnormal, even though there was no lesion.…”

An update on the management of glandular fever (infectious mononucleosis) and its sequelae caused by Epstein–Barr virus (HHV-4): new and emerging treatment strategies

“…Coinfections with EBV, HCMV, and HHV-6 are common in CFS illness. 23,[53][54][55] Valganciclovir is the first-therapeutic choice vs HCMV and HHV-6 CFS infections.…”