A chronic moderate methionine administration induced hyperhomocysteinemia associated with cardiovascular disease phenotype in the sand rat Psammomys obesus

Zerrouk, Fouzia; Chaouad, B.; Ghoul, A.; Chalour, Naima; Moulahoum, Anissa; Khiari, Zineb; Cherifi, Mohamed el Hadi; Aouichat, Souhila; Houali, Karim; Benazzoug, Yasmina

doi:10.5603/fhc.a2022.0013

Cited by 2 publications

(2 citation statements)

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“…Elevated intake of methionine and subsequent homocysteine levels have been linked to an increased risk of cardiovascular disease, primarily attributed to the induction of oxidative stress and inflammatory cascades. Methionine-induced hyperhomocysteinemia has been associated with various alterations in the structure of the aortic wall, including thickening of layers, endothelial cell hyperplasia, microthrombi formation, atheromatous plaque development, collagen accumulation, and an increase in interlamellar spaces [ 39 ]. Observational studies have also indicated a potential association between hyperhomocysteinemia and the progression of AAA [ 40 ].…”

Section: Resultsmentioning

confidence: 99%

Bridging the gap: Navigating the impact of dietary supplements on abdominal aortic aneurysm progression- A systematic review

Amirsardari,

Khalili,

Behnoush

et al. 2024

PLoS ONE

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Background Vitamins D, E, A, B, C, and Omega-3 play crucial roles in modulating inflammatory and oxidative stress pathways, both implicated in abdominal aortic aneurysm (AAA) development. Recent research has explored the potential impact of dietary supplements on AAA progression. The systematic review aims to assess interventional studies investigating the effects of various dietary supplements on the development and severity of abdominal aortic aneurysms. Method A systematic search using relevant keywords related to abdominal aortic aneurysm and dietary supplements was conducted across four databases (PubMed, Embase, Scopus, and Web of Science). Quality assessment for animal studies employed SYRCLE and the Cochrane Collaboration Risk of Bias Tool for randomized control trials. The study protocol is registered in PROSPERO under the registry code CRD42023455958. Results Supplementation with Omega-3, Vitamins A, C, D, E, and the Vitamin B family exhibited positive effects in AAA progression. These supplements contributed to a reduction in AAA diameter, elastin degradation, inflammatory responses, and reactive oxygen species. Additional supplements such as Zinc, methionine, and phytoestrogen also played roles in mitigating AAA progression. Conclusion The findings of this study underscore the potential role of dietary supplements in the progression of AAA. Predominantly based on animal studies, the results indicate that these supplements can limit AAA progression, primarily evidenced by their ability to mitigate inflammatory processes and oxidative stress pathways.

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Section: Resultsmentioning

confidence: 99%

Bridging the gap: Navigating the impact of dietary supplements on abdominal aortic aneurysm progression- A systematic review

Amirsardari,

Khalili,

Behnoush

et al. 2024

PLoS ONE

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“…High levels of Hcy in the blood plasma are registered in patients with a deficiency of vitamins B6, B9, B12, excess intake of methionine. In addition, bad habits, a sedentary lifestyle and the use of certain medicines are associated with HHcy [10,11,18].…”

Section: Introductionmentioning

confidence: 99%

Histological and histochemical changes in liver tissue of young rats with hyperhomocysteinemia

Halahan¹

2023

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. The decisive place in the synthesis and subsequent metabolism of homocysteine (Hcy) belongs to the liver, where, in particular, transsulfation and remethylation processes take place. It has been proven that organ tissue damage can cause hyperhomocysteinemia (HHcy). Changes in the structural and functional parameters of the liver tissue under the conditions of a significant and long-term increase in blood serum Hcy are still insufficiently studied. Modeling the state of chronic HHcy and studying the features of histological changes in liver tissue at different levels of structural organization is an urgent task. The aim of the research is to study morphological and histochemical changes in the liver tissue of young rats with HHcy. The experiment was carried out on 22 white non-linear young – aged 1-2 months, male rats. During the study, the animals were divided into two groups – control and experimental. Chronic persistent HHcy was modeled by administering thiolactone Hcy in a dose of 200 mg/kg of body weight intragastrically for 60 days to the rats of the experimental group. Histological preparations were studied using a SEO SСAN light microscope and photo-documented using a Vision CCD Camera. Succinate dehydrogenase was detected histochemically according to the Nakhlas method. To study the specifics of glycogen accumulation in hepatocytes, sections were stained using Schiff's reagent, after preliminary treatment with iodic acid (PAS reaction) in the Shabadash modification. It was established that the administration of thiolactone Hcy to young rats at a dose of 200 mg/kg led to impaired blood supply, destructive changes and growth of connective tissue in the liver. Moderate changes in the hepatocyte plates organization, a decrease in the mitotic activity of hepatocytes, and the development of fatty and vacuole-hydropic dystrophy were recorded. Histochemical studies of the liver of animals of the research group established a decrease in the activity of the succinate dehydrogenase enzyme and glycogen content in hepatocytes.

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A chronic moderate methionine administration induced hyperhomocysteinemia associated with cardiovascular disease phenotype in the sand rat Psammomys obesus

Cited by 2 publications

References 55 publications

Bridging the gap: Navigating the impact of dietary supplements on abdominal aortic aneurysm progression- A systematic review

Bridging the gap: Navigating the impact of dietary supplements on abdominal aortic aneurysm progression- A systematic review

Histological and histochemical changes in liver tissue of young rats with hyperhomocysteinemia

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